3197-25-9

Basic information

• Product Name: 5-(N-PHTHALIMIDO)-2-PENTANONE
• Synonyms: 5-PHTHALIMIDO-2-PENTANONE;5-(N-PHTHALIMIDO)-2-PENTANONE;2-(4-OXOPENTYL)-1H-ISOINDOLE-1,3(2H)-DIONE;2-(4-oxopentyl)isoindole-1,3-dione;2-(4-Oxopentyl)Isoindoline-1,3-Dione;2-(4-Oxopentyl)
• CAS NO: 3197-25-9
• Molecular Formula: C₁₃H₁₃NO₃
• Molecular Weight: 231.25
• Mol File: 3197-25-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 74-75°
• Boiling Point: 385.104 °C at 760 mmHg
• Flash Point: 175.54 °C
• Appearance: /
• Density: 1.238 g/cm³
• Vapor Pressure: 3.9E-06mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 5-(N-PHTHALIMIDO)-2-PENTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(N-PHTHALIMIDO)-2-PENTANONE(3197-25-9)
• EPA Substance Registry System: 5-(N-PHTHALIMIDO)-2-PENTANONE(3197-25-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3197-25-9(Hazardous Substances Data)

Usage

Description

5-(N-PHTHALIMIDO)-2-PENTANONE, also known as 2-(4-Oxopentyl)-1H-isoindole-1,3(2H)-dione, is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which includes a phthalimide group attached to a pentanone moiety.

Uses

Used in Pharmaceutical Synthesis:
5-(N-PHTHALIMIDO)-2-PENTANONE is used as an intermediate in the synthesis of 5,6-Orthoquinone Primaquine-d6 Hydrobromide (O697512), an isotope-labeled compound of 5,6-Orthoquinone Primaquine (O697510). 5-(N-PHTHALIMIDO)-2-PENTANONE is utilized in the study of the differential pharmacological and toxicological properties of primaquine enantiomers.
Primaquine is currently the only approved drug for the treatment and radical cure of Plasmodium vivax malaria, a parasitic disease caused by the Plasmodium vivax species. The study of its enantiomers helps in understanding the differences in their biological activities and potential side effects, which can lead to the development of safer and more effective treatments for malaria.

InChI:InChI=1/C13H13NO3/c1-9(15)5-4-8-14-12(16)10-6-2-3-7-11(10)13(14)17/h2-3,6-7H,4-5,8H2,1H3

Upstream product

• 5891-21-4 5-chloro-2-pentanone 
• 136918-14-4 phthalimide 
• 872791-67-8 (4-phthalimido-butyryl)-malonic acid diethyl ester 
• 1074-82-4 potassium phtalimide 
• 141-78-6 ethyl acetate 
• 97320-85-9 N-[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-phthalimide 
• 6097-07-0 N-(pent-4-ynyl)phthalimide 
• 1071-73-4 5-Hydroxy-2-pentanone 
• 96-47-9 2-methyltetrahydrofuran 
• 86864-59-7 5-((tert-butyldimethylsilyl)oxy)pentan-2-one 
• 818-56-4 4-methoxypentan-1-ol 
• 126680-65-7 5-((tert-butyldimethylsilyl)oxy)pentan-2-ol 
• 71510-39-9 2-pentyl-1H-isoindole-1,3(2H)-dione 
• 111957-98-3 Pent-4-en-2-ol 

Downstream Products

• 96068-70-1 2-(2-(1-benzyl-5-methoxy-2-methyl-1H-indol-3-yl)ethyl)isoindoline-1,3-dione 
• 41306-64-3 2-(5-bromo-4-oxo-pentyl)-isoindole-1,3-dione 
• 112357-34-3 3-bromo-5-phtalimido-2-pentanone 
• 36507-31-0 4-methylhistamine 
• 40546-33-6 3-[imidazol-4⁽⁵⁾-yl]propylamine 
• 112357-43-4 Homohistamine dipicrate 
• 126434-97-7 2-[2-(5-Methyl-1H-imidazol-4-yl)-ethyl]-isoindole-1,3-dione 
• 142457-00-9 Amthamine dihydrobromide 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 441-91-8 2-(1-benzyl-5-methoxy-2-methyl-indol-3-yl)-ethylamine 
• 106635-87-4 2,6-dimethoxy-4-methyl-8-<(4-phthalimido-1-methylbutyl)amino>-5-<3-(trifluoromethyl)phenoxy>quinoline 
• 1260253-91-5 8-[(1-methyl-4-phthalimido)-butyl]-amino-6-methoxy-4-methyl-5-phenyl-2-trifluoromethyl-quinoline 
• 1260253-94-8 8-[(1-methyl-4-phthalimido)-butyl]-amino-6-methoxy-5-(3-methoxy)-phenyl-4-methyl-2-trifluoromethyl-quinoline 
• 1260253-95-9 8-[(1-methyl-4-phthalimido)-butyl]-amino-6-methoxy-4-methyl-5-(3-methylphenyl)-2-trifluoromethyl-quinoline 

Relevant articles and documents

Synthesis of calix[4]pyrrole-based acrylate and acrylamide monomers: Precursors for preparation of anion-selective polymer membranes

Octamethylcalix[4]pyrrole derivatives with hydroxy alkyl and amino alkyl side chains were prepared and converted into the corresponding acrylate and acrylamide derivatives, respectively. Georg Thieme Verlag Stuttgart.

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5-phenoxy primaquine analogs and the tetraoxane hybrid as antimalarial agents

The rapid emergence of drug resistance to the current antimalarial agents has led to the urgent need for the discovery of new and effective compounds. In this work, a series of 5-phenoxy primaquine analogs with 8-aminoquinoline core (7a–7h) was synthesize

Substituted imidazo[4,5-c]quinoline macrocyclic compound as multi-target kinase inhibitor

The invention discloses a substituted imidazo[4,5-c]quinoline macrocyclic compound as a multi-target kinase inhibitor, and relates to a compound represented by a formula (I) or a pharmaceutically acceptable salt, a solvate, a polymorphic substance or an isomer thereof, and applications of the compound in preparation of a medicine for treating ALK-mediated diseases.