36507-31-0

Basic information

• Product Name: 4-methylhistamine
• Synonyms: 4-methylhistamine;5-Methyl-1H-imidazole-4-ethanamine;5-Methylhistamine;1H-Imidazole-4-ethanamine, 5-methyl-;4-Methylhistamine hydride;C025566;5-(2-Aminoethyl)-4-methylimidazole;1H-Imidazole-5-ethanamine,4-methyl-
• CAS NO: 36507-31-0
• Molecular Formula: C₆H₁₁N₃
• Molecular Weight: 125.17
• Mol File: 36507-31-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 345°Cat760mmHg
• Flash Point: 189.3°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 6.34E-05mmHg at 25°C
• CAS DataBase Reference: 4-methylhistamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylhistamine(36507-31-0)
• EPA Substance Registry System: 4-methylhistamine(36507-31-0)

Safety Data

• Hazardous Substances Data: 36507-31-0(Hazardous Substances Data)

Usage

Description

4-Methylhistamine, also known as N-methylhistamine, is an aralkylamino compound that is histamine bearing a methyl substituent at the 5 position on the ring. It is a naturally occurring substance found in various biological systems and has been implicated in a range of physiological processes.

Uses

Used in Pharmaceutical Industry:
4-Methylhistamine is used as a pharmaceutical agent for its potential therapeutic applications. It has been shown to possess anti-inflammatory, anti-allergic, and immunomodulatory properties, making it a promising candidate for the treatment of various inflammatory and allergic conditions.
Used in Research Applications:
4-Methylhistamine is used as a research tool for studying the biological functions and mechanisms of histamine and its receptors. It can be used to investigate the role of histamine in various physiological processes, such as neurotransmission, immune response, and cell proliferation.
Used in Diagnostic Applications:
4-Methylhistamine can be used as a biomarker for the diagnosis and monitoring of certain diseases and conditions. Its levels in biological samples, such as blood, urine, or cerebrospinal fluid, can provide valuable information about the severity and progression of the disease, as well as the effectiveness of treatment.
Used in Drug Development:
4-Methylhistamine can be used in the development of new drugs targeting histamine receptors. It can serve as a lead compound or a template for the design and synthesis of novel histamine receptor agonists or antagonists with improved pharmacological properties and therapeutic potential.

InChI:InChI=1/C6H11N3.2ClH/c1-5-6(2-3-7)9-4-8-5;;/h4H,2-3,7H2,1H3,(H,8,9);2*1H

Upstream product

• 5891-21-4 5-chloro-2-pentanone 
• 112357-34-3 3-bromo-5-phtalimido-2-pentanone 
• 3197-25-9 2-(4-oxopentyl)isoindole-1,3-dione 
• 126434-97-7 2-[2-(5-Methyl-1H-imidazol-4-yl)-ethyl]-isoindole-1,3-dione 
• 69435-38-7 4-(2-chloroethyl)-5-methyl-1H-imidazole hydrochloride 
• 51667-66-4 4⁽⁵⁾-(cyanomethyl)-5⁽⁴⁾-methylimidazole 

Downstream Products

• 110-54-3 hexane 

Relevant articles and documents

An Alternative Synthesis of Homohistamine and Structurally Related (Imidazole-4-yl)alkylamines

Bromination of N-(4-oxopentyl)phthalimide (3) leads to isomeric bromoketones 2a and 2e, which undergo cyclisation with formamidine in liquid ammonia to yield homohistamine (1a) and 5-methylhistamine (1e).Similarly racemic α-methyl- (1b) and 2-methylhomohistamine (1c) are synthesized.The resolution of 1b is achieved using (+)- and (-)-di-O-(4-toluoyl)tartaric acid. 1 are intermediates in the synthesis of impromidine like, H2-histaminergic compounds. - Key words: Bromination of Methylketones, Halomethylketones, Histamine H2-Agonists, Homohistamine, Chiral Aminoalkylimidazoles

2H-imidazole-2-thione derivatives

Imidazole derivatives which are useful intermediates for the production of compounds having pharmacological activity at histamine H2 receptors. A specific compound of the present invention is 4-(4-aminobutyl)-1,3-dihydro-5-methyl-2H-imidazole-2