322-97-4 Usage
Description
7-(TRIFLUOROMETHYL)-4-QUINOLINOL, also known as 4-Hydroxy-7-(trifluoromethyl)quinoline, is a light greyish-beige powder with unique chemical properties. It is a quinoline derivative that has been synthesized for various applications due to its distinct structure and characteristics.
Uses
Used in Pharmaceutical Industry:
7-(TRIFLUOROMETHYL)-4-QUINOLINOL is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 7-(TRIFLUOROMETHYL)-4-QUINOLINOL is used as a building block for creating more complex molecules. Its trifluoromethyl group and quinoline core provide a versatile platform for further chemical reactions and modifications, leading to the development of novel compounds with specific properties and applications.
For example, it has been used in the synthesis of 4[[7-(trifluoromethyl)quinolin-4-yl]oxy]pthalonitrile, showcasing its utility in creating new chemical entities with potential applications in various industries.
Overall, 7-(TRIFLUOROMETHYL)-4-QUINOLINOL is a versatile compound with applications in the pharmaceutical and chemical synthesis industries, primarily due to its unique structure and the potential for further development into new drugs and complex molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 322-97-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,2 and 2 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 322-97:
(5*3)+(4*2)+(3*2)+(2*9)+(1*7)=54
54 % 10 = 4
So 322-97-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H8F3NO/c16-11-4-3-9(14(17)15(11)18)8-1-2-10-12(7-8)19-6-5-13(10)20/h1-7H,(H,19,20)
322-97-4Relevant articles and documents
NOVEL QUINOLINE DERIVATIVES
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Page/Page column 45-46, (2008/06/13)
The invention relates to compounds represented by Formula (I): and to pharmaceutically acceptable salts or solvates of said compounds, wherein each of A, R3-8, X3, X5, m, and n are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).
Structure-activity relationships for antiplasmodial activity among 7- substituted 4-aminoquinolines
De, Dibyendu,Krogstad, Frances M.,Byers, Larry D.,Krogstad, Donald J.
, p. 4918 - 4926 (2007/10/03)
Aminoquinolines (AQs) with diaminoalkane side chains (-HNRNEt2) shorter or longer than the isopentyl side chain [-HNCHMe(CH2)3NEt2] of chloroquine are active against both chloroquine-susceptible and -resistant Plasmodium falciparum. (De, D.; et al. Am. J. Trop. Med. Hyg. 1996, 55, 579-583). In the studies reported here, we examined structure-activity relationships (SARs) among AQs with different N,N-diethyldiaminoalkane side chains and different substituents at the 7-position occupied by Cl in chloroquine. 7-Iodo- and 7- bromo-AQs with diaminoalkane side chains [-HN(CH2)2NEt2, -HN(CH2)3NEt2, or -HNCHMeCH2NEt2] were as active as the corresponding 7-chloro-AQs against both chloroquine-susceptible and -resistant P. falciparum (IC50s of 3-12 nM). In contrast, with one exception, 7-fluoro-AQs and 7-trifluoromethyl-AQs were less active against chloroquine-susceptible P. falciparum (IC50s of 15-50 nM) and substantially less active against chloroquine-resistant P. falciparum (IC50s of 18-500 nM). Furthermore, most 7-OMe-AQs were inactive against both chloroquine-susceptible (IC50s of 17-150 nM) and -resistant P. falciparum (IC50s of 90-3000 nM).