574-92-5 Usage
Description
4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINECARBOXYLIC ACID is an organic compound characterized by its beige crystalline powder form. It is a derivative of quinolinecarboxylic acid with a hydroxyl group at the 4th position, a trifluoromethyl group at the 7th position, and a carboxylic acid group at the 3rd position. 4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINECARBOXYLIC ACID is known for its unique chemical properties and potential applications in various fields.
Uses
Used in Chemical Synthesis:
4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINECARBOXYLIC ACID is used as a key intermediate in the synthesis of various complex organic molecules, particularly in the preparation of (4-hydroxy-7-trifluoromethylquinolin-3-yl)formaldehyde. 4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINECARBOXYLIC ACID serves as a building block for the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINECARBOXYLIC ACID is used as a starting material for the development of novel drugs with potential therapeutic applications. Its unique chemical structure allows for the creation of new molecules with specific biological activities, targeting various diseases and medical conditions.
Used in Research and Development:
4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINECARBOXYLIC ACID is also utilized in research and development laboratories for the study of its chemical properties, reactivity, and potential applications in various fields. Researchers use this compound to explore new reaction pathways, develop innovative synthetic methods, and gain insights into the structure-activity relationships of related molecules.
Used in Material Science:
In the field of material science, 4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINECARBOXYLIC ACID may find applications in the development of new materials with specific properties, such as optical, electronic, or magnetic functionalities. Its unique chemical structure can be exploited to design and synthesize novel materials with tailored characteristics for various applications, including sensors, displays, and energy storage devices.
Check Digit Verification of cas no
The CAS Registry Mumber 574-92-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,7 and 4 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 574-92:
(5*5)+(4*7)+(3*4)+(2*9)+(1*2)=85
85 % 10 = 5
So 574-92-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H6F3NO3/c12-11(13,14)5-1-2-6-8(3-5)15-4-7(9(6)16)10(17)18/h1-4H,(H,15,16)(H,17,18)
574-92-5Relevant articles and documents
Reactivity and Anticancer Assessment of 4-Hydroxyquinoline Derivatives
El-Metwally, S. A.,Regal, M. K. A.,Shabana, S. S.
, p. 307 - 314 (2020)
Abstract: Ethyl 4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylate (1) exhibits a moderate cytotoxic activity against the MCF-7 mammary gland cancer cell line and HePG2 hepatocellular carcinoma cell line and a weak activity against the HCT-116 human colorectal carcinoma cell line. In order to enhance the cytotoxic activity of this compound, it was modified by changing the side-chain substituent and/or forming a new heterocyclic ring fused to the pyridine ring. Heating compound 1 with chloroacetyl chloride gave a mixture of two isomeric O-acylation products ethyl 4-(2-chloroacetoxy)-7-(trifluoromethyl)-quinoline-3-carboxylate and 3-chloro-8-(trifluoromethyl)-2H-pyrano[3,2-c]quinoline-2,4(3H)-dione, whereas the reaction with acetyl chloride in NaOH formed an N-acylation product 1-acetyl-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic acid. The reactions of compound 1 with urea, thiourea, hydrazine hydrate, hydroxylamine, o-phenylenediamine, phenyl isothiocyanate, and ethyl acetoacetate yielded the corresponding condensation products 1-[4-oxo-7-(trifluoromethyl)-3,4-dihydroquinoline-3-carbonyl)]urea, 1-[4-oxo-7-(trifluoromethyl)-3,4-dihydroquinoline-3-carbonyl)]thiourea, 7-(trifluoromethyl)-1,2-dihydropyrazolo[4,3-c]quinolin-3-one, 7-(trifluoromethyl)isoxazolo[4,5-c]quinolin-3(2H)-one, 3-(trifluoromethyl)-13H-benzo[2,3][1,4]diazepino[6,5-c]quinolin-7-ol, 3-phenyl-2-thioxo-8-(trifluoromethyl)-2,3-dihydro-4H-[1,3]oxazino[5,6-c]quinolin-4-one and ethyl 8-(trifluoromethyl)-2-methyl-4-oxo-4H-pyrano[3,2-c]quinolone 3-carboxylate, respectively. The structures of the synthesized compounds were confirmed by elemental analysis and spectral data.
Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
-
, (2008/06/13)
Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.
