3228-02-2

Basic information

• Product Name: 4-ISOPROPYL-3-METHYLPHENOL
• Synonyms: BIOSOL;3-METHYL-4-ISOPROPYLPHENOL;4-ISOPROPYL-M-CRESOL;4-ISOPROPYL-3-METHYLPHENOL;1-Hydroxy-3-methyl-4-isopropylbenzene;2-Methyl-4-(1-methylethyl)phenol;2-methyl-4-(1-methylethyl)-phenol;2-Methyl-4-isopropylphenol
• CAS NO: 3228-02-2
• Molecular Formula: C₁₀H₁₄O
• Molecular Weight: 150.22
• EINECS: 221-761-7
• Product Categories: Organic Building Blocks;Oxygen Compounds;Phenols;Building Blocks;C9 to C20+;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;pharma. cosmetic, personal care, antifungal and antibacterial
• Mol File: 3228-02-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 111-114 °C(lit.)
• Boiling Point: 246 °C
• Flash Point: 104.1 °C
• Appearance: White needle crystal
• Density: 0.9688 (estimate)
• Vapor Pressure: 1.81Pa at 25℃
• Refractive Index: 1.5115 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 10.36±0.18(Predicted)
• Water Solubility: 210mg/L at 20℃
• CAS DataBase Reference: 4-ISOPROPYL-3-METHYLPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ISOPROPYL-3-METHYLPHENOL(3228-02-2)
• EPA Substance Registry System: 4-ISOPROPYL-3-METHYLPHENOL(3228-02-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• RIDADR: 1759
• WGK Germany: 2
• RTECS: GZ7170000
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 3228-02-2(Hazardous Substances Data)

Usage

Description

4-Isopropyl-3-methylphenol, also known as isopropylmethylphenol, is a white crystal powder with unique chemical properties. It is a valuable reagent in the field of organic chemistry, particularly for cross-coupling reactions.

Uses

Used in Chemical Synthesis:
4-Isopropyl-3-methylphenol is used as a reagent for cross-coupling reactions in the chemical synthesis industry. Its unique structure and properties make it a versatile building block for creating a wide range of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Isopropyl-3-methylphenol is used as an intermediate in the synthesis of various drugs and pharmaceutical compounds. Its ability to participate in cross-coupling reactions allows for the development of new and innovative medications.
Used in Flavor and Fragrance Industry:
4-Isopropyl-3-methylphenol is also utilized in the flavor and fragrance industry, where it serves as a key component in the creation of various scents and flavors. Its unique chemical properties contribute to the development of distinct and appealing sensory experiences.
Used in Material Science:
In the field of material science, 4-Isopropyl-3-methylphenol is employed as a component in the development of advanced materials with specific properties. Its involvement in cross-coupling reactions enables the synthesis of novel materials with tailored characteristics for various applications.

Flammability and Explosibility

Nonflammable

InChI:InChI=1S/C10H14O/c1-7(2)10-5-4-9(11)6-8(10)3/h4-7,11H,1-3H3

Synthetic route

3-methyl-2-isopropyl-phenol (3228-01-1) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8)

Conditions	Yield
With carbon disulfide; aluminium trichloride at 50 - 60℃;
With phosphorus pentoxide at 210 - 215℃; Erhitzen des Reaktionsprodukts mit konz. wss. Alkalilauge auf 220grad;

1-isopropoxy-3-methylbenzene (19177-04-9) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8)

Conditions	Yield
Einleiten von BF3;
With aluminium trichloride
With phosphorus pentoxide at 130℃; Erhitzen mit konz. wss. Alkalilauge auf 220grad;

6-tert-butyl-4-isopropyl-3-methylphenol (30061-94-0) → 3-Methyl-4-isopropylphenol (3228-02-2)

Conditions	Yield
With Fuller-earth; benzene at 265℃;

propene (187737-37-7) + 3-methyl-phenol (108-39-4) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8)

Conditions	Yield
With solid phosphoric acid/silica support titania at 250℃; under 12001.2 Torr; for 1h; Autoclave;
With Fuller's Earth at 230℃;
With phosphoric acid at 230℃;
With phosphorus pentoxide at 230℃;
With zinc(II) chloride at 230℃;

1-Chloropropane (540-54-5) + 3-methyl-phenol (108-39-4) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8)

Conditions	Yield
With zinc(II) oxide at 230℃;
With zinc(II) oxide at 230℃;

isopropyl chloride (75-29-6) + 3-methyl-phenol (108-39-4) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8)

Conditions	Yield
With aluminium trichloride; 1,2-dichloro-ethane at -10 - 0℃;

di-isopropyl ether (108-20-3) + 3-methyl-phenol (108-39-4) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8)

Conditions	Yield
With Fuller's Earth at 140 - 150℃;
With Fuller's Earth at 230 - 250℃;
at 350℃;

Dipropyl ether (111-43-3) + 3-methyl-phenol (108-39-4) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8)

Conditions	Yield
With Fuller's Earth at 140 - 150℃;
With Fuller's Earth at 230 - 250℃;

3-methyl-phenol (108-39-4) + isopropyl alcohol (67-63-0) → 3-Methyl-4-isopropylphenol (3228-02-2)

Conditions	Yield
With sulfuric acid at 80℃;
With amberlyst-15; carbon dioxide; hydrogen; platinum at 200℃; under 75006 Torr; for 8h; Friedel-Craft alkylation;	30 % Chromat.

3-methyl-phenol (108-39-4) + isopropyl alcohol (67-63-0) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8)

Conditions	Yield
With tungstophosphoric acid at 160℃;
With phosphoric acid at 150℃;
With aluminium trichloride at 125℃;

3-methyl-phenol (108-39-4) → 3-Methyl-4-isopropylphenol (3228-02-2)

Conditions	Yield
With sulfuric acid Erwaermen mit Propanol-(2) unter Zusatz von konz. Schwefelsaeure auf 65-70grad und anschliessendes Erhitzen mit Wasser unter Durchleiten von Wasserdampf;

3-methyl-phenol (108-39-4) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8)

Conditions	Yield
at 120 - 125℃; Sulfurieren, Beh. der Sulfonsaeure mit Isopropylalkohol od. Propylalkohol in Gegenw. v. Schwefelsaeure u. nachf. Destillieren mit Wasserdampf;
durch Sulfurieren; Behandeln der Sulfonsaeure mit Propylalkohol oder Isopropylalkohol in Gegenwart von Schwefelsaeure und folgende Destillation mit Wasserdampf bei 120-125grad;
durch Sulfonieren, Behandeln der Sulfonsaeure mit Propylalkohol oder Isopropylalkohol in Gegenwart von Schwefelsaeure und nachfolgende Destillation mit Wasserdampf bei 120-125grad;

4-Isopropyl-3-methylaniline (4534-10-5) → 3-Methyl-4-isopropylphenol (3228-02-2)

Conditions	Yield
With sulfuric acid; sodium nitrite

1-(2-Hydroxy-5-isopropyl-4-methyl-phenyl)-propan-1-one (121194-62-5) → 3-Methyl-4-isopropylphenol (3228-02-2) + 1-(2-hydroxy-4-methyl-phenyl)-propan-1-one (2886-52-4)

Conditions	Yield
With aluminium trichloride In chlorobenzene 1.) 20 deg C, 20 h, 2.) 50 deg C, 4 h, 3) 100 deg C, 2 h;	A 6 % Chromat. B 85 % Chromat.

phosphoric acid (86119-84-8, 7664-38-2) + 3-methyl-phenol (108-39-4) + isopropyl alcohol (67-63-0) → 3-Methyl-4-isopropylphenol (3228-02-2)

Conditions	Yield
at 150℃;

1-Chloropropane (540-54-5) + 3-methyl-phenol (108-39-4) + ZnO → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8)

Conditions	Yield
at 230℃;

aluminium trichloride (7446-70-0) + isopropyl chloride (75-29-6) + 3-methyl-phenol (108-39-4) + 1,2-dichloro-ethane (107-06-2) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-isopropyl-5-methylphenol (3228-03-3)

Conditions	Yield
at -13 - -11℃;

di-isopropyl ether (108-20-3) + 3-methyl-phenol (108-39-4) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 350℃;

aluminium trichloride (7446-70-0) + di-isopropyl ether (108-20-3) + 3-methyl-phenol (108-39-4) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 150 - 350℃; auch in Gegenwart anderer Katalysatoren;

di-isopropyl ether (108-20-3) + sulfuric acid (7664-93-9) + 3-methyl-phenol (108-39-4) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 160 - 190℃;

3-methyl-phenol (108-39-4) + isopropyl alcohol (67-63-0) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 350℃;

aluminium trichloride (7446-70-0) + 3-methyl-phenol (108-39-4) + isopropyl alcohol (67-63-0) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 150 - 350℃; auch in Gegenwart anderer Katalysatoren;

phosphoric acid (86119-84-8, 7664-38-2) + 3-methyl-phenol (108-39-4) + isopropyl alcohol (67-63-0) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 50 - 60℃;

perchloric acid (7601-90-3) + water (7732-18-5) + 3-methyl-phenol (108-39-4) + isopropyl alcohol (67-63-0) → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 100℃;

propan-1-ol (71-23-8) + 3-methyl-phenol (108-39-4) + active Fuller's earth → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 140 - 150℃;

Dipropyl ether (111-43-3) + 3-methyl-phenol (108-39-4) + active Fuller's earth → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 140 - 150℃;

3-methyl-phenol (108-39-4) + isopropyl alcohol (67-63-0) + tungstophosphoric acid → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 160℃;
at 160℃;

propan-1-ol (71-23-8) + 3-methyl-phenol (108-39-4) + ZnCl2 → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 200 - 250℃;

Dipropyl ether (111-43-3) + 3-methyl-phenol (108-39-4) + ZnCl2 → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + 3-methyl-5-isopropyl-phenol and diisopropyl-m-cresols

Conditions	Yield
at 200 - 250℃;

propene (187737-37-7) + 3-methyl-phenol (108-39-4) + Fuller's earth → 3-Methyl-4-isopropylphenol (3228-02-2) + thymol (89-83-8) + 3-methyl-2-isopropyl-phenol (3228-01-1) + diisopropyl-m-cresols

Conditions	Yield
at 170 - 230℃; (oder andere Katalysatoren);

3-Methyl-4-isopropylphenol (3228-02-2) + bromoacetic acid methyl ester (96-32-2) → methyl 2-(4-isopropyl-3-methylphenoxy)-acetate (649774-36-7)

Conditions	Yield
With potassium carbonate In butanone for 20h; Heating / reflux;	100%
With potassium carbonate In butanone for 20h; Heating / reflux;	100%
With potassium hydroxide In tetrahydrofuran; dimethyl sulfoxide at 20℃; for 2h;	84.4%

3-Methyl-4-isopropylphenol (3228-02-2) + triisopropylsilyl chloride (13154-24-0) → tri(1-methylethyl)-(4-(1-methylethyl)-3-methylphenoxy)silane

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃; Sealed tube;	99%

3-Methyl-4-isopropylphenol (3228-02-2) + C15H10Cl2N2O2 → N-(4-(5-chlorobenzo[d]oxazol-2-yl)phenyl)-2-(4-isopropyl-3-methylphenoxy)acetamide

Conditions	Yield
With caesium carbonate In acetonitrile at 20℃; Inert atmosphere;	96%

3-Methyl-4-isopropylphenol (3228-02-2) + thianthrene cation radical perchlorate (35787-71-4) → 5-(2-Hydroxy-5-isopropyl-4-methyl-phenyl)-thianthren-5-ium; perchlorate

Conditions	Yield
In acetonitrile for 7h;	95%

3-Methyl-4-isopropylphenol (3228-02-2) + benzyl bromide (100-39-0) → 4-(isopropyl)-3-methylphenyl benzyl ether (101747-14-2)

Conditions	Yield
With potassium hydroxide In tetrahydrofuran; dimethyl sulfoxide at 20℃; for 2h;	94.7%

3-Methyl-4-isopropylphenol (3228-02-2) + propionic acid anhydride (123-62-6) → 4-(isopropyl)-3-methylphenyl propionate (101267-52-1)

Conditions	Yield
With pyridine for 24h; Heating;	94%

3-Methyl-4-isopropylphenol (3228-02-2) + trifluoromethylsulfonic anhydride (358-23-6) → C11H13F3O3S

Conditions	Yield
With triethylamine In dichloromethane for 1.5h;	94%
With triethylamine In toluene at 20℃; Flow reactor;

3-Methyl-4-isopropylphenol (3228-02-2) + acetic anhydride (108-24-7) → 3-methyl-4-(1-methylethyl)phenyl ethanoate (38770-70-6)

Conditions	Yield
	93%

3-Methyl-4-isopropylphenol (3228-02-2) + phenylacetyl chloride (103-80-0) → 4-isopropyl-3-methylphenyl phenylacetate

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 5h;	92.3%

3-Methyl-4-isopropylphenol (3228-02-2) + 4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride (59703-00-3) → 4-isopropyl-3-methylphenyl N-(4-ethyl-2,3-dioxo-1-piperazine)carbamate

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 4h;	92%

tert.-butylhydroperoxide (75-91-2) + 3-Methyl-4-isopropylphenol (3228-02-2) → 4-(tert-butylperoxy)-4-isopropyl-3-methyl-2,5-cyclohexadien-1-one

Conditions	Yield
With tris(triphenylphosphine)ruthenium(II) chloride In benzene at 20℃; Inert atmosphere;	92%

3-Methyl-4-isopropylphenol (3228-02-2) + Heptanoic acid chloride (2528-61-2) → 3-methyl-4-(1-methylethyl)phenyl heptanoate (129375-06-0)

Conditions	Yield
With pyridine	91%

3-Methyl-4-isopropylphenol (3228-02-2) + 2,4,5-trifluorobenzoyl chloride (88419-56-1) → 4-isopropyl-3-methylphenyl 2,4,5-trifluorobenzoate

Conditions	Yield
Stage #1: 3-Methyl-4-isopropylphenol With triethylamine In acetonitrile for 0.5h; Stage #2: 2,4,5-trifluorobenzoyl chloride In acetonitrile at 0 - 20℃; for 3h;	90.2%

3-Methyl-4-isopropylphenol (3228-02-2) + tertiary butyl chloride (507-20-0) → 6-tert-butyl-4-isopropyl-3-methylphenol (30061-94-0)

Conditions	Yield
at 80 - 85℃; for 24h;	90%

3-Methyl-4-isopropylphenol (3228-02-2) + phenylglyoxal hydrate (1074-12-0) → 1-(2-hydroxy-5-isopropyl-4-methylphenyl)-2-phenylethane-1,2-dione

Conditions	Yield
With copper(II) acetate monohydrate In toluene at 60℃; for 5h;	90%

3-Methyl-4-isopropylphenol (3228-02-2) + 2-Fluorobenzaldehyde (446-52-6) → C17H18O2

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 1h;	90%
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 2h;	80%

3-Methyl-4-isopropylphenol (3228-02-2) + 1,2,3,4,6-penta-O-acetyl-D-glucose → C24H32O10

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 3h;	88.8%

3-Methyl-4-isopropylphenol (3228-02-2) + 2,3,6-trifluorobenzoyl chloride → 4-isopropyl-3-methylphenyl 2,3,6-trifluorobenzoate

Conditions	Yield
Stage #1: 3-Methyl-4-isopropylphenol With triethylamine In acetonitrile for 0.5h; Stage #2: 2,3,6-trifluorobenzoyl chloride In acetonitrile at 0 - 20℃; for 3h;	85.3%

3-Methyl-4-isopropylphenol (3228-02-2) + benzoyl chloride (98-88-4) → 3-methyl-4-(1-methylethyl)phenyl benzoate (143815-16-1)

Conditions	Yield
With sodium hydroxide for 2h; Ambient temperature;	85%

3-Methyl-4-isopropylphenol (3228-02-2) + β-ferrocenylacrylic acid (67462-91-3, 12154-65-3) → 6-isopropyl-7-methyl-4-ferrocenylchroman-2-one

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃;	83%

3-Methyl-4-isopropylphenol (3228-02-2) + 3,5-dichlorobenzoyl chloride (2905-62-6) → 4-isopropyl-3-methylphenyl 3,5-dichlorobenzoate

Conditions	Yield
Stage #1: 3-Methyl-4-isopropylphenol With triethylamine In acetonitrile for 0.5h; Stage #2: 3,5-dichlorobenzoyl chloride In acetonitrile at 0 - 20℃; for 3h;	81.3%

3-Methyl-4-isopropylphenol (3228-02-2) + 2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one (94088-75-2) → 4-isopropyl-3-methylphenyl (2-aminothiazol-4-yl)methoxyiminoacetate

Conditions	Yield
With triethylamine In methanol; dichloromethane for 8h;	75.2%

3-Methyl-4-isopropylphenol (3228-02-2) → 2,4,6-triazido-4-isopropyl-3-methylcyclohexa-2,5-dien-1-one

Conditions	Yield
With Amberlyst A26-resin bound iodine azide In acetonitrile at 20℃; for 2h; Catalytic behavior; Inert atmosphere;	75%

3-Methyl-4-isopropylphenol (3228-02-2) + 4-methoxy-benzoyl chloride (100-07-2) → 3-methyl-4-(1-methylethyl)phenyl 4-methoxybenzoate (129375-07-1)

Conditions	Yield
With pyridine	74%

3-Methyl-4-isopropylphenol (3228-02-2) + methyl 3-(2-bromoacetamido)benzoate (257622-59-6) → methyl 3-[2-(4-isopropyl-3-methyl-phenoxy)-acetylamino]-benzoate (430470-37-4)

Conditions	Yield
With potassium carbonate In butanone for 12h; Heating / reflux;	73%
With potassium carbonate In butanone for 12h; Heating / reflux;	73%

3-Methyl-4-isopropylphenol (3228-02-2) + 2-chloro-3-quinoline carboxaldehyde (73568-25-9) → 2-(4-isopropyl-3-methylphenoxy)quinoline-3-carbaldehyde

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 150℃;	72%

3-Methyl-4-isopropylphenol (3228-02-2) → (+/-)-4-Fluoro-4-isopropyl-3-methylcyclohexa-2,5-dienone

Conditions	Yield
With Selectfluor In acetonitrile at 22℃; for 7h; Fluorination;	71%

3-Methyl-4-isopropylphenol (3228-02-2) → 2-bromo-5-methyl-4-(1-methylethyl)phenol (143815-14-9)

Conditions	Yield
With bromine In tetrachloromethane; diethyl ether	70%

tert.-butylhydroperoxide (75-91-2) + 3-Methyl-4-isopropylphenol (3228-02-2) + 1-(tert-butylperoxy)-1,2-benziodoxol-3(1H)-one (142260-70-6) → 4-(tert-butylperoxy)-4-isopropyl-3-methyl-2,5-cyclohexadien-1-one

Conditions	Yield
In ethyl acetate at 50℃; for 5.5h;	70%

3-Methyl-4-isopropylphenol (3228-02-2) + 1,3-bis(bromomethyl)-4-nitrophenol (98437-49-1) → 2,6-bis(2-hydroxy-4-methyl-5-isopropylbenzyl)-4-nitrophenol (193359-91-0)

Conditions	Yield
In acetic acid at 90℃; for 5h;	65%

Upstream product

• 3228-01-1 3-methyl-2-isopropyl-phenol 
• 19177-04-9 1-isopropoxy-3-methylbenzene 
• 30061-94-0 6-tert-butyl-4-isopropyl-3-methylphenol 
• 187737-37-7 propene 
• 108-39-4 3-methyl-phenol 
• 540-54-5 1-Chloropropane 
• 75-29-6 isopropyl chloride 
• 108-20-3 di-isopropyl ether 
• 111-43-3 Dipropyl ether 
• 67-63-0 isopropyl alcohol 
• 4534-10-5 4-Isopropyl-3-methylaniline 
• 121194-62-5 1-(2-Hydroxy-5-isopropyl-4-methyl-phenyl)-propan-1-one 
• 86119-84-8 phosphoric acid 
• 7446-70-0 aluminium trichloride 

Downstream Products

• 110356-69-9 4-Isopropyl-5-methyl-2-piperidinomethyl-phenol 
• 5436-42-0 2-isopropyl-5-methoxytoluene 
• 33641-86-0 p-thymol ethyl ester 
• 104175-28-2 6-hydroxy-3-isopropyl-2-methyl-benzaldehyde 
• 89-83-8 thymol 
• 1705-73-3 4-isopropyl-3-methyl-2,6-dinitro-phenol 
• 4482-26-2 4-isopropyl-5-methyl-[1,2]benzoquinone 
• 23053-85-2 6-hydroxy-3-isopropyl-2-methyl-benzoic acid 
• 54121-40-3 2-chloro-4-isopropyl-5-methyl-phenol 
• 101747-13-1 2-Benzyl-4-isopropyl-3-methyl-phenol 
• 102956-70-7 2,6-Dibenzyl-4-isopropyl-3-methyl-phenol 
• 105401-43-2 (4-isopropyl-3-methyl-phenoxy)-acetic acid 
• 38770-70-6 3-methyl-4-(1-methylethyl)phenyl ethanoate 
• 3845-31-6 O-<α,α'-Dichlorisopropyl>-O-<4-isopropyl-3-methyl-phenyl>-schwefligsaeureester 

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METHOD FOR PRODUCING ALKYLPHENOLS

PROBLEM TO BE SOLVED: To provide an economically excellent and industrially advantageous method for producing 6-tert-butyl-4-isopropyl-3-methylphenol and 4-isopropyl-3-methylphenol. SOLUTION: The method for producing 6-tert-butyl-4-isopropyl-3-methylphenol by isopropylation of 6-tert-butyl-3-methylphenol is characterized by using an isopropylating agent in an amount of 1.0 mol equivalent or more based on 6-tert-butyl-3-methylphenol. The method for producing 4-isopropyl-3-methylphenol comprises subjecting 6-tert-butyl-4-isopropyl-3-methylphenol produced by the above-mentioned production method to debutylation. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

PRODUCTION METHOD OF DIALKYLPHENOL

PROBLEM TO BE SOLVED: To provide a method of producing a dialkylphenol safely in a high yield which causes a reaction to proceed under relatively low temperature and pressure conditions. SOLUTION: A method of producing a dialkylphenol comprises reacting m-cresol with an organic acid isopropyl ester, such as isopropyl acetate, in the presence of a zeolite type catalyst, especially β-type zeolite catalyst at a reaction pressure of about 0-1.0 MPa and a reaction temperature of about 180-200°C to obtain a dialkylphenol, such as 4-isopropyl-3-methylphenol or thymol. COPYRIGHT: (C)2016,JPOandINPIT