32329-20-7

Basic information

• Product Name: 3-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE
• Synonyms: 3-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE;3-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine
• CAS NO: 32329-20-7
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.19
• Mol File: 32329-20-7.mol
• Article Data: 22

Chemical Properties

• Melting Point: 98-100°C
• Boiling Point: 216.7°Cat760mmHg
• Flash Point: 62.2°C
• Appearance: /
• Density: 1.078g/cm³
• Vapor Pressure: 0.0171mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.44±0.40(Predicted)
• CAS DataBase Reference: 3-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE(32329-20-7)
• EPA Substance Registry System: 3-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE(32329-20-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 32329-20-7(Hazardous Substances Data)

Usage

General Description

3-Methyl-3,4-dihydro-2H-1,4-benzoxazine, also known as 3-Methyl-3,4-dihydro-2H-1,4-benzoxazin-2-one, is an organic compound with the chemical formula C9H9NO2. It is a cyclic aminal and a heterocyclic amine that is used in organic synthesis as a building block for various pharmaceuticals and agrochemicals. 3-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE has potential applications in the manufacturing of polymers and resins, as well as in the pharmaceutical industry. It is also used as a chemical intermediate in the production of various fine chemicals and dyes. 3-Methyl-3,4-dihydro-2H-1,4-benzoxazine is a white to light yellow solid and is known to be toxic if ingested or inhaled, as well as an irritant to the eyes and skin.

InChI:InChI=1/C9H11NO/c1-7-6-11-9-5-3-2-4-8(9)10-7/h2-5,7,10H,6H2,1H3/t7-/m1/s1

Upstream product

• 5330-66-5 1-(2-nitrophenoxy)-propan-2-one 
• 79204-91-4 N-(1-Methyl-2-phenoxy-ethyl)-hydroxylamine 
• 79204-92-5 C₁₁H₁₅NO₃ 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 13414-54-5 2-[(2-methyl-2-propenyl)oxy]-1-nitrobenzene 
• 88-75-5 2-hydroxynitrobenzene 
• 30263-61-7 phenoxyacetone oxime 
• 79204-99-2 C₁₁H₁₃NO₃ 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 676-58-4 methylmagnesium chloride 
• 854666-04-9 1-(2-aminophenoxy)propan-2-ol 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 95-55-6 2-amino-phenol 

Downstream Products

• 602297-58-5 N-[N'-tosyl-(2S)-propyl]-(3R)-2,3-dihydro-3-methyl-4H-1,4-benzoxazine 
• 98730-04-2 4-dichloroacetyl-3,4-dihydro-3-methyl-2H-1,4-benzoxazine 
• 1239896-99-1 (3S)-2,3-dihydro-3-methyl-N-[N-phthaloyl-(2S)-2-phenylglycyl]-4H-1,4-benzoxazine 
• 1239897-02-9 (2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline 
• 1239896-97-9 (2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline 
• 1290176-67-8 (3S)-2,3-dihydro-3-methyl-4-[o-methyl-N-phthaloyl-(S)-tyrosyl]-4H-1,4-benzoxazine 
• 200125-70-8 (S)-2-methyl-1,2,3,4-tetrahydroquinoline 
• 1780-19-4 (R)-1,2,3,4-tetrahydroquinaldine 
• 1290176-66-7 (2S)-2-methyl-1-[o-methyl-N-phthaloyl-(S)-tyrosyl]-1,2,3,4-tetrahydroquinoline 
• 1290176-64-5 (2S)-2-methyl-1-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline 
• 1290176-65-6 (3S)-2,3-dihydro-3-methyl-4-[3-(4-nitrophenyl)-nphthaloyl-(S)-alanyl]-4H-1,4-benzoxazine 

Relevant articles and documents

Synthesis, Crystal Structure, and Biological Activity of 4-phenoxyacetyl-substituted methyl-3,4-dihydro-2H-1,4-benzoxazine

Two novel substituted benzoxazine derivatives have been synthesized through reduction, cyclization, and acylation reactions. The target compounds were characterized by IR, 1H-NMR, 13C-NMR, and HRMS. The single-crystal structures of t

Metal-free tandem cyclization/hydrosilylation to construct tetrahydroquinoxalines

A one-pot tandem procedure involving cyclization and sequential hydrosilylation of imines and amides under the catalysis of B(C6F5)3 has been developed for the step-economical construction of 1,2,3,4-tetrahydroquinoxalines directly from readily available 1,2-diaminobenzenes, α-ketoesters and low-cost, safe polymethylhydrosiloxane (PMHS). This metal-free approach provides various products in good to excellent yields, and displays a wide range of substrate scope and a high degree of functional group tolerance even to reduction-sensitive moieties. The choice of hydrosilanes is critical to the catalysis, and PMHS has proved to be optimal. Decreasing the amount of PMHS could enable the reaction to stop at the 3,4-dihydroquinoxalin-2(1H)-one stage. The procedure is convenient and scalable, and neither a dried solvent nor an inert atmosphere is required. Moreover, the enantioselective construction of these products was explored, and promising results were achieved.

Ruthenium-Catalyzed Amination of Secondary Alcohols Using Borrowing Hydrogen Methodology

A new ruthenium complex catalyzes the amination of primary and secondary alcohols and the regioselective mono- and sequential diamination of diols via the borrowing hydrogen pathway. Several variations on new intra- and intermolecular cyclizations of aminoalcohols, diols, and diamines lead to heterocyclic ring systems.