324-80-1

Basic information

• Product Name: 2-(4-FLUOROPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE
• Synonyms: 2-(4-FLUOROPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE;2-(4-FLUOROPHENYL)-5-PHENYLOXAZOLE;2-(4-fluorophenyl)-5-phenyl-1,3-oxazole
• CAS NO: 324-80-1
• Molecular Formula: C₁₅H₁₀FNO
• Molecular Weight: 240.23
• EINECS: 206-305-7
• Product Categories: Scintillators
• Mol File: 324-80-1.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 381.8°Cat760mmHg
• Flash Point: 184.7°C
• Appearance: /
• Density: 1.194g/cm³
• Vapor Pressure: 1.08E-05mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 2-(4-FLUOROPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE(324-80-1)
• EPA Substance Registry System: 2-(4-FLUOROPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE(324-80-1)

Safety Data

• Hazardous Substances Data: 324-80-1(Hazardous Substances Data)

Usage

General Description

2-(4-Fluorophenyl)-5-phenyl-1,3,4-oxadiazole is a chemical compound with a molecular formula C14H9FN2O. It is a heterocyclic compound containing an oxadiazole ring, and it is used in organic synthesis and pharmaceutical research. The compound has potential applications in the development of new drugs, as oxadiazole derivatives have been studied for their antibacterial, antifungal, and anticancer properties. Additionally, the fluorophenyl and phenyl groups in the compound contribute to its unique chemical and physical properties, making it a valuable building block for the synthesis of novel compounds with diverse biological activities. Overall, 2-(4-Fluorophenyl)-5-phenyl-1,3,4-oxadiazole is a versatile chemical with potential applications in drug discovery and material science.

InChI:InChI=1/C15H10FNO/c16-13-8-6-12(7-9-13)15-17-10-14(18-15)11-4-2-1-3-5-11/h1-10H

Upstream product

• 2368-16-3 4-Fluoro-N-[1-(2-oxo-2-phenylethyl)]benzamide 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 403-43-0 4-fluorobenzoyl chloride 
• 532-27-4 1-chloroacetophenone 
• 1006-68-4 5-phenyloxazole 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 98-88-4 benzoyl chloride 
• 148890-53-3 4-fluorobenzyl isocyanide 
• 459-57-4 4-fluorobenzaldehyde 
• 100-42-5 styrene 
• 140-75-0 para-fluorobenzylamine 
• 1011-51-4 5-(4-methoxyphenyl)-1,3-oxazole 
• 225916-39-2 2-(4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 1393689-78-5 (E)-4-fluoro-N-styrylbenzamide 

Relevant articles and documents

Divergent Conversion of N-Acyl-isoxazol-5(2 H)-ones to Oxazoles and 1,3-Oxazin-6-ones Using Photoredox Catalysis

The fragmentation of N-acyl-isoxazol-5-ones using visible light photoredox catalysis has been disclosed. The catalyst-controlled divergent mechanisms, namely the oxidative and reductive quenching catalytic cycle, are utilized. Various oxazoles and 1,3-oxazin-6-ones are selectively obtained from the same isoxazol-5-one skeleton under mild conditions.

Metal-free iodine(iii)-promoted synthesis of 2,5-diaryloxazoles

A nonmetal-catalyzed oxidative cyclization to achieve 2,5-disubstituted oxazoles from inexpensive and readily available substituted chalcone, (diacetoxyiodo)benzene (PIDA) and ammonium acetate (NH4OAc) at room temperature is described. The reaction forms a variety of 2,5-diaryloxazoles in good to excellent yields with broad substrate scope under mild conditions without the requirement of ligands and additional bases.

Synthesis of Substituted Oxazoles by Visible-Light Photocatalysis

A simple and practical method for the synthesis of substituted oxazoles has been developed using readily available α-bromoketones and benzylamines by visible-light photocatalysis at room temperature. The process, which requires 1 mol % of [Ru(bpy)3]Cl2 photocatalyst with K3PO4 and CCl3Br, is effective for accessing a variety of valuable oxazole compounds. The synthetic utility of our protocol was also demonstrated by preparing a natural product, texaline.