32446-66-5Relevant articles and documents
Base-free oxidation of alcohols enabled by nickel(ii)-catalyzed transfer dehydrogenation
Ye, Danfeng,Liu, Zhiyuan,Sessler, Jonathan L.,Lei, Chuanhu
supporting information, p. 11811 - 11814 (2020/10/13)
An efficient nickel(ii)-catalyzed transfer dehydrogenation oxidation of alcohols is reported that relies on cyclohexanone as the formal oxidant and does not require the use of an external base. The synthetic utility of this protocol is demonstratedviathe facile oxidation of structurally complicated natural products.
A novel process for the synthesis of substantially pure Letrozole
Suman,Vijayabhaskar,NageswaraRao,Syam Kumar,VenkateswaraRao
, p. 1 - 8 (2019/08/08)
This article demonstrates an improved novel and practical synthesis of oral non-steroidal aromatase inhibitor (AI) Letrozole in a five-stage synthetic process in excellent yields. Key steps of the synthesis involve the condensation of 4-(chloro(4-cyanophenyl)methyl)benzamide with 1H-1,2,4-triazole and further its dehydration to Letrozole by using trifluoroacetic anhydride at low temperature.