324572-77-2

Basic information

• Product Name: 8-methoxy-2-(2-methyl-pyridin-4-ylmethyl)-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester
• Synonyms: 8-methoxy-2-(2-methyl-pyridin-4-ylmethyl)-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester
• CAS NO: 324572-77-2
• Molecular Weight: 505.527
• Mol File: 324572-77-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-methoxy-2-(2-methyl-pyridin-4-ylmethyl)-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 8-methoxy-2-(2-methyl-pyridin-4-ylmethyl)-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester(324572-77-2)
• EPA Substance Registry System: 8-methoxy-2-(2-methyl-pyridin-4-ylmethyl)-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester(324572-77-2)

Safety Data

• Hazardous Substances Data: 324572-77-2(Hazardous Substances Data)

Upstream product

• 324573-83-3 8-methoxy-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1H-pyrano[3,4-c]pyridine-3-carboxylic acid 
• 324573-63-9 2-methoxy-4-(3,4,5-trimethoxy-benzoyl)-nicotinic acid 
• 324573-56-0 4-methoxy-1-(3,4,5-trimethoxy-phenyl)-1H-furo[3,4-c]pyridin-3-one 
• 125335-74-2 3-Diisopropylaminocarbonyl-2-methoxypyridine 
• 67-56-1 methanol 
• 94413-70-4 1-(2-methylpyridin-4-yl)methanamine 
• 324573-86-6 3-hydroxy-8-methoxy-1-oxo-4-(3,4,5-trimethoxy-phenyl)-3,4-dihydro-1H-pyrano[3,4-c]pyridine-3-carboxylic acid 

Downstream Products

• 324572-92-1 2-((2-methylpyridin-4-yl)methyl)-4-(3,4,5-trimethoxyphenyl)-8-((pyrimidin-2-yl)methoxy)-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester 
• 324572-80-7 8-chloro-2-(2-methyl-pyridin-4-ylmethyl)-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester 

Relevant articles and documents

1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors

Novel 1,7- and 2,7-naphthyridine derivatives, designed by the introduction of nitrogen atom into the phenyl ring of previously reported 4-aryl-1-isoquinolinone derivatives, were disclosed as a new structural class of potent and specific PDE5 inhibitors. Among them, 2,7-naphthyridine 4c showed potent PDE5 inhibition (IC50=0.23 nM) and one of the best PDE5 specificities against PDEs1-4,6 (>100,000-fold selective versus PDE1-4, 240-fold selective vs PDE6). This compound showed more potent relaxant effects on isolated rabbit corpus cavernosum (EC30=5.0 nM) than Sildenafil (EC30=8.7 nM). The compound 4c (T-0156) was selected for further biological and pharmacological evaluation of erectile dysfunction.