94413-70-4

Basic information

• Product Name: 1-(2-methylpyridin-4-yl)methanamine
• Synonyms: 1-(2-methylpyridin-4-yl)methanamine;1-(2-methylpyridin-4-yl)methanamine(SALTDATA: FREE);(2-Methylpyridin-4-yl)MethanaMine;(2-Methylpyridin-4-yl)
• CAS NO: 94413-70-4
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• EINECS: 604-604-1
• Mol File: 94413-70-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 220.8°C at 760 mmHg
• Flash Point: 108°C
• Appearance: /
• Density: 1.027g/cm³
• Vapor Pressure: 0.111mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.84±0.29(Predicted)
• CAS DataBase Reference: 1-(2-methylpyridin-4-yl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methylpyridin-4-yl)methanamine(94413-70-4)
• EPA Substance Registry System: 1-(2-methylpyridin-4-yl)methanamine(94413-70-4)

Safety Data

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45
• RIDADR: UN2811
• Hazardous Substances Data: 94413-70-4(Hazardous Substances Data)

Usage

General Description

1-(2-methylpyridin-4-yl)methanamine, also known as 2-methyl-4-(1-pyridin-2-ylethyl)aniline, is a chemical compound with the molecular formula C12H15N. It is a derivative of pyridine and is commonly used in the synthesis of pharmaceuticals and agrochemicals. This chemical has been studied for its potential use in treating various neurological disorders and has also been investigated for its antimicrobial and antiviral properties. Additionally, 1-(2-methylpyridin-4-yl)methanamine has been researched for its potential role in the development of novel materials and as a building block in organic synthesis. Overall, this compound has shown promising potential for various applications and continues to be of interest in the fields of medicine, chemistry, and materials science.

InChI:InChI=1/C7H10N2/c1-6-4-7(5-8)2-3-9-6/h2-4H,5,8H2,1H3

Upstream product

• 2214-53-1 2-methyl-4-cyanopyridine 
• 22282-99-1 4-bromo-2-methylpyridine 
• 13508-96-8 2-methyl-4-nitro-pyridine 
• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 33252-30-1 2-chloro-4-pyridinenitrile 

Downstream Products

• 324572-77-2 8-methoxy-2-(2-methyl-pyridin-4-ylmethyl)-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester 
• 324572-92-1 2-((2-methylpyridin-4-yl)methyl)-4-(3,4,5-trimethoxyphenyl)-8-((pyrimidin-2-yl)methoxy)-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester 

Relevant articles and documents

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology

Phosphatidylinositol 4-kinase IIIβ (PI4KB) is indispensable for the replication of various positive-sense single stranded RNA viruses, which hijack this cellular enzyme to remodel intracellular membranes of infected cells to set up the functional replication machinery. Therefore, the inhibition of this PI4K isoform leads to the arrest of viral replication. Here, we report on the synthesis of novel PI4KB inhibitors, which were rationally designed based on two distinct structural types of inhibitors that bind in the ATP binding side of PI4KB. These “hybrids” not only excel in outstanding inhibitory activity but also show high selectivity to PI4KB compared to other kinases. Thus, these compounds exert selective nanomolar or even subnanomolar activity against PI4KB as well as profound antiviral effect against hepatitis C virus, human rhinovirus, and coxsackievirus B3. Our crystallographic analysis unveiled the exact position of the side chains and explains their extensive contribution to the inhibitory activity.

TACHYKININ RECEPTOR ANTAGONISTS

The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.