325490-29-7

Basic information

• Product Name: (1R)-1-phenylprop-2-en-1-amine
• Synonyms: (1R)-1-phenylprop-2-en-1-amine
• CAS NO: 325490-29-7
• Molecular Weight: 133.193
• Mol File: 325490-29-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: (1R)-1-phenylprop-2-en-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-1-phenylprop-2-en-1-amine(325490-29-7)
• EPA Substance Registry System: (1R)-1-phenylprop-2-en-1-amine(325490-29-7)

Safety Data

• Hazardous Substances Data: 325490-29-7(Hazardous Substances Data)

Usage

Description

(1R)-1-phenylprop-2-en-1-amine, also known as alpha-methylbenzylamine, is a primary amine compound with the chemical formula C9H11N. It is a colorless liquid with a strong ammonia-like odor and is commonly used as a precursor and intermediate in the synthesis of pharmaceuticals and other organic compounds.

Uses

Used in Pharmaceutical Industry:
(1R)-1-phenylprop-2-en-1-amine is used as a precursor and intermediate for the synthesis of various pharmaceuticals and organic compounds. Its amine group makes it a versatile compound that can participate in a wide range of chemical reactions, making it an important component in the production of various products in the chemical and pharmaceutical industries.
Used in Chemical Reactions:
(1R)-1-phenylprop-2-en-1-amine is used as a reagent in chemical reactions due to its ability to participate in a wide range of chemical reactions, making it an important component in the production of various products in the chemical and pharmaceutical industries.
Used in Production of Polymers and Other Materials:
(1R)-1-phenylprop-2-en-1-amine is used as a building block in the production of polymers and other materials, contributing to the development of new and innovative products in various industries.

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 100-52-7 benzaldehyde 
• 343338-28-3 (S)-2-methylpropane-2-sulfinamide 
• 86537-61-3 ethyl cinnamylcarbonate 
• 85217-69-2 cinnamyl methyl carbonate 
• 104-54-1 3-Phenylpropenol 
• 1044148-86-8 2-((R)-1-phenylallyl)isoindoline-1,3-dione 
• 1023743-85-2 (R_S,R)-N-(1-phenylallyl)-2-methylpropylsulfinamide 
• 154614-38-7 (+/-)-N-1-acetyl-1-phenyl-2-propenylamine 
• 123772-66-7 N-(α-phenylpropargyl)acetamide 
• 368447-65-8 benzaldehyde (E)-O-[(1S)-2-hydroxy-1-phenylethyl]oxime 
• 688362-68-7 (R)-(+)-N-acetyl-1-phenylprop-2-enylamine 
• 502157-97-3 (2S)-2-phenyl-2-({[(1R)-1-phenyl-2-propenyl]amino}oxy)ethanol 
• 4393-21-9 1-(phenyl)allylamine 

Downstream Products

• 168126-69-0 4-methyl-N-[(1R)-1-phenylprop-2-en-1-yl]benzene-1-sulfonamide 
• 1181394-32-0 C₁₉H₂₁NO 
• 488151-84-4 (R)-N-allyl-1-phenylprop-2-en-1-amine 
• 959119-75-6 tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(1R)-1-phenylprop-2-en-1-yl]amino}ethyl)benzoate 
• 103150-32-9 (1S,2R)-N-1-(1-phenyl-2,3-dihydroxypropyl)benzamide 
• 500021-54-5 tert-butyl (1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-5-hydroxy-1-phenylpentenylcarbamate 
• 500021-53-4 tert-butyl (1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenyl-4-pentenylcarbamate 
• 757195-52-1 tert-butyl (1S)-2,3-dihydroxy-1-phenylpropylcarbamate 
• 163061-19-6 (2S)-2-tert-butoxycarbonylamino-2-phenylacetaldehyde 

Relevant articles and documents

Chemoselective, Regioselective, and Enantioselective Allylations of NH2OH under Iridium Catalysis

The utilization of unprotected NH2OH, which is not only an oxygen nucleophile but also a nitrogen nucleophile, in iridium-catalyzed allylic substitution is realized under mild conditions. The chemoselectivity, stereoselectivity, and multiple al

Asymmetric synthesis of α- And β-amino acids by diastereoselective addition of triorganozincates to N-(tert-butanesulfinyl) imines

The diastereoselective addition of triorganozincates to (R)-N-(tert-butanesulfinyl)imines has been used as a key step to achieve the synthesis of highly enantiomerically enriched N-protected α- and β-amino acids. Desulfinylation of the addition products followed by benzoylation of the nitrogen atom of the obtained primary amines and oxidation of one of the substituents on the carbon atom connected to the nitrogen complete the sequence. Using the same configuration in the sulfinyl chiral auxiliary, α-amino acids with the (R) or the (S) configuration can be prepared by choosing the proper combination of imine and organozincate. α,α- Disubstituted α-amino esters with high enantiomeric purity can also be prepared when α-imino esters are the starting substrates.

Application of the addition of triorganozincates to N-(tert-butanesulfinyl)imines to the enantioselective synthesis of α-amino acids

Highly enantiomerically enriched N-protected α-amino acids can be easily prepared from optically pure N-(tert-butanesulfinyl)imines by a four-step sequence involving: diastereoselective addition of a triorganozincate to the imine, removal of the sulfinyl group, benzoylation of the nitrogen atom of the obtained primary amine and oxidation of one of the substituents on the carbon atom α to the nitrogen. Using the same configuration in the sulfinyl chiral auxiliary, amino acids with the (R) or the (S) configuration can be prepared by choosing the proper combination of imine and organozincate. α,α-Disubstituted α-amino esters with high optical purity can also be prepared by the diastereoselective addition of trialkylzincates to α-imino esters.