326-58-9

Basic information

• Product Name: benzo-1,3-dioxol-5-ol acetate
• Synonyms: benzo-1,3-dioxol-5-ol acetate;1,3-Benzodioxol-5-ol acetate;1,3-benzodioxol-5-yl acetate;1,3-benzodioxol-5-yl ethanoate;acetic acid 1,3-benzodioxol-5-yl ester;1,3-Benzodioxol-5-ol,5-acetate;Benzo[d][1,3]dioxol-5-yl acetate;Acetic acid benzo[1,3]dioxol-5-yl ester
• CAS NO: 326-58-9
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.15742
• EINECS: 206-310-4
• Mol File: 326-58-9.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 273.7°Cat760mmHg
• Flash Point: 118.8°C
• Appearance: /
• Density: 1.303g/cm³
• Vapor Pressure: 0.00564mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: benzo-1,3-dioxol-5-ol acetate(CAS DataBase Reference)
• NIST Chemistry Reference: benzo-1,3-dioxol-5-ol acetate(326-58-9)
• EPA Substance Registry System: benzo-1,3-dioxol-5-ol acetate(326-58-9)

Safety Data

• Hazardous Substances Data: 326-58-9(Hazardous Substances Data)

Usage

Uses

Sesamol Acetate could be a useful for preparing antifungal agents.

InChI:InChI=1/C9H8O4/c1-6(10)13-7-2-3-8-9(4-7)12-5-11-8/h2-4H,5H2,1H3

Upstream product

• 533-31-3 Sesamol 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 79-21-0 peracetic acid 
• 120-57-0 piperonal 
• 104-15-4 toluene-4-sulfonic acid 
• 64-19-7 acetic acid 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 108-05-4 vinyl acetate 
• 108-22-5 Isopropenyl acetate 
• 274-09-9 Methylenedioxybenzene 

Downstream Products

• 66003-50-7 1-<4,5-(methylenedioxy)-2-hydroxyphenyl>ethanone 
• 7107-08-6 INV-75 
• 5460-53-7 1-acetoxy-2-bromo-4,5-methylenedioxybenzene 
• 342890-13-5 6-[(E)-2-(Benzyloxy-diisopropyl-silanyl)-vinyl]-benzo[1,3]dioxol-5-ol 
• 96249-79-5 2'-hydroxy-4',5'-methylenedioxychalcone 
• 4424-13-9 6,7-methylenedioxy-2-phenyl-4H-benzopyran-4-one 
• 4388-66-3 6-phenyl-6,7-dihydro-8H-[1,3]dioxolo[4,5-g]chromen-8-one 
• 857982-72-0 3-hydroxy-1-(6-hydroxy-benzo[1,3]dioxol-5-yl)-3-phenyl-propan-1-one 
• 7107-10-0 4-hydroxy-5-nitro-1,2,methylenedioxybenzene 
• 6316-25-2 5-benzoyloxy-6-nitro-benzo[1,3]dioxole 
• 533-31-3 Sesamol 

Relevant articles and documents

An unexpected Pummerer rearrangement in the synthetic route to ethyl (2′-hydroxy-4′,5′-methylenedioxyphenyl)acetate: An alternative approach to 2,3-dimethylthio benzofurans

The synthesis of ethyl (2′-hydroxy-4′,5′-methylendioxophenyl)acetate, a fragment of the antihyperglycemic natural coumarin subcoriacin, is reported. We found an expeditious route to the title compound in five steps. Final metal catalyzed acid ethanolysis of the vinylic 1,1-methylthio methylsulfoxide derivative afforded the required aryl acetic ester, but in the absence of metal catalyst, an unexpected Pummerer rearrangement produced the 2,3-dimethylthiofuran derivative as the major product. This last result provides an alternative entry to 2,3-dimethlythiobenzofurans.

TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS

The present invention discloses a series of tricyclic compounds and use thereof in preparing a medicament for treating a disease related to CRBN protein. Specifically, the present invention discloses a derivative compound of formula (1) or a pharmaceutically acceptable salt thereof.

Protection of COOH and OH groups in acid, base and salt free reactions

We report an iron-catalyzed general functional group protection method with inexpensive reagents. This environmentally benign process does not use acids or bases, and does not produce waste products. Further purification beyond filtration and evaporation is, in most cases, unnecessary. Free COOH and OH groups can be protected in a one-pot reaction.