3260-63-7

Basic information

• Product Name: N-METHYLINDOXYL ACETATE
• Synonyms: AKOS 219-11;AKOS AU36-M372;N-METHYLINDOXYL ACETATE;1-methyl-1h-indol-3-oacetate(ester);n-Methylindoxylacetatecrystalline;1-Methyl-1H-indol-3-ol acetate;Acetic acid 1-methyl-1H-indole-3-yl ester;NMIA
• CAS NO: 3260-63-7
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21
• Mol File: 3260-63-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 56.5 °C(Solv: water (7732-18-5))
• Boiling Point: 326.6°Cat760mmHg
• Flash Point: 151.3°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 0.000214mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-METHYLINDOXYL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYLINDOXYL ACETATE(3260-63-7)
• EPA Substance Registry System: N-METHYLINDOXYL ACETATE(3260-63-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3260-63-7(Hazardous Substances Data)

Usage

General Description

N-Methylindoxyl acetate is a chemical compound that is commonly used in the production of flavors and fragrances. It is an ester, with a structure that includes a methyl group and an indoxyl group linked to an acetate. N-METHYLINDOXYL ACETATE is known for its strong, floral odor and is often used as a perfume ingredient or in the creation of fruit and floral scents. N-Methylindoxyl acetate is also used as a flavoring agent in food products, providing a sweet and floral taste. It is a versatile compound that is valued for its unique aroma and taste-enhancing properties.

InChI:InChI=1/C11H11NO2/c1-8(13)14-11-7-12(2)10-6-4-3-5-9(10)11/h3-7H,1-2H3

Upstream product

• 119-68-6 N-Methylanthranilic acid 
• 21716-67-6 2-(carboxymethyl)-N-methylanthranilic acid 
• 108-24-7 acetic anhydride 
• 603-76-9 1-methylindole 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 120-72-9 indole 
• 618-40-6 1-Methyl-1-phenylhydrazine 
• 213339-77-6 1-methyl-2-(triisopropylsilyl)-1H-indole 

Downstream Products

• 38072-62-7 2-(4-Chlorphenyl)-methyliden-1-methylindolin-3-on 
• 38072-61-6 2-(4-Chlorphenyl)-methyliden-1-methylindolin-3-on 
• 38072-58-1 (E)-2-benzylidene-1-methylindolin-3-one 
• 38072-57-0 (Z)-2-benzylidene-1-methylindolin-3-one 
• 84584-97-4 (E/Z)-2-benzylidene-1-methylindolin-3-one 
• 84353-53-7 2-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-1-methyl-1,2-dihydro-indol-3-one 
• 84353-53-7 2-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-1-methyl-1,2-dihydro-indol-3-one 
• 99430-49-6 3-hydroxy-1-methylindole-2-carbaldehyde 
• 99430-58-7 3-Oxo-1-methyl-2-(N-methyl-N-phenylaminomethylene)indole 
• 84353-40-2 2-[(3-Hydroxy-1-methyl-1H-indol-2-yl)-phenyl-methyl]-malononitrile 
• 84353-51-5 3-cyano-2,3-dihydro-3-oxo-4-phenylpyrano<3,2-b>-N-methylindole 
• 84353-41-3 2-[(4-Chloro-phenyl)-(3-hydroxy-1-methyl-1H-indol-2-yl)-methyl]-malononitrile 
• 84353-42-4 2-[(3-Hydroxy-1-methyl-1H-indol-2-yl)-(4-methoxy-phenyl)-methyl]-malononitrile 
• 84353-45-7 Acetic acid 2-(2,2-dicyano-1-phenyl-ethyl)-1-methyl-1H-indol-3-yl ester 

Relevant articles and documents

Co(III)-Catalyzed, Internal and Terminal Alkyne-Compatible Synthesis of Indoles

A Co(III)-catalyzed, internal and terminal alkyne-compatible indole synthesis protocol is reported herein. The N-amino (hydrazine) group imparts distinct, diverse reactivity patterns for directed C-H functionalization/cyclization reactions. Notable synthetic features include regioselectivity for a meta-substituted arylhydrazine, regioselectivity for a chain-branched terminal alkyne, formal incorporation of an acetylenic unit through C2-desilylation on a C2-silylated indole derivative, formal inversion of regioselectivity through consecutive C3-derivatization and C2-desilylation processes, and formal bond migration for a linear-chain terminal alkyne.

Pd-catalyzed direct and selective C-H functionalization: C3-acetoxylation of indoles

Direct functionalization of C-H bonds has been a hot topic in organic chemistry during recent years. Arenes-one of the most abundant chemical motifs-usually have multiple C-H bonds. Although, some examples of direct functionalizations of arenes have been