327-95-7 Usage
General Description
4-Fluoroisophthalic acid is a chemical compound with the molecular formula C8H5FO4. It is a derivative of isophthalic acid, and it contains a fluorine atom in the para position relative to the carboxylic acid group. 4-Fluoroisophthalic acid is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and functional materials. It is also utilized in the production of fluorescent dyes, polymers, and coordination complexes. 4-Fluoroisophthalic acid is a white solid with a high melting point and is generally handled and stored as a solid powder. It is important to handle this compound with caution due to its potential irritant and toxic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 327-95-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,2 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 327-95:
(5*3)+(4*2)+(3*7)+(2*9)+(1*5)=67
67 % 10 = 7
So 327-95-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H5FO4/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3H,(H,10,11)(H,12,13)
327-95-7Relevant articles and documents
The first regioselective metalation and functionalization of unprotected 4-halobenzoic acids
Gohier, Frederic,Castanet, Anne-Sophie,Mortier, Jacques
, p. 1501 - 1504 (2007/10/03)
(Chemical Equation Presented) By treatment with s-BuLi, s-BuLi/TMEDA, or t-BuLi at ～-78°C, 4-fluoro- and 4-chlorobenzoic acids (1a,b) are metalated preferentially in the position adjacent to the carboxylate. A complete reversal in regioselectivity is observed for 1a when treated with LTMP; a sequential process involving a rapid intraaggregate lithiation through a quasi dianion complex "QUADAC" is postulated to explain the unusual reactivity of Me2S2 and I2.
