452-65-3

Basic information

• Product Name: 1,3-Dimethyl-4-fluorobenzene
• Synonyms: 1,3-Dimethyl-4-fluorobenzene;4-Fluoro-m-xylene, 2,4-Dimethyl-1-fluorobenzene
• CAS NO: 452-65-3
• Molecular Formula: C₈H₉F
• Molecular Weight: 124.1554632
• Product Categories: Fluorine series
• Mol File: 452-65-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 145℃
• Flash Point: 31℃
• Appearance: /
• Density: 0.983
• Refractive Index: 1.4739
• CAS DataBase Reference: 1,3-Dimethyl-4-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dimethyl-4-fluorobenzene(452-65-3)
• EPA Substance Registry System: 1,3-Dimethyl-4-fluorobenzene(452-65-3)

Safety Data

• Hazardous Substances Data: 452-65-3(Hazardous Substances Data)

Usage

General Description

1,3-Dimethyl-4-fluorobenzene, also known as p-Fluoro-m-xylene, is a chemical compound with the molecular formula C8H9F. It is a colorless liquid at room temperature and is commonly used as a solvent in laboratory and industrial processes. This chemical is a member of the xylene family and is widely used in the production of dyes, resins, and pharmaceuticals. It is also a key intermediate in the synthesis of various organic compounds, making it an important building block in chemical manufacturing. Additionally, 1,3-Dimethyl-4-fluorobenzene has potential applications in the field of medicine and pharmacology, with ongoing research exploring its use in drug development and discovery. However, it is important to handle this chemical with caution as it can be harmful if ingested or inhaled, and can cause skin and eye irritation upon contact.

Upstream product

• 108-38-3 m-xylene 
• 95-68-1 2,4-Xylidine 
• 35709-99-0 chlorocarbonic acid-(2,4-dimethyl-phenyl ester) 
• 87241-52-9 2,4-dimethylphenyl trifluoromethanesulfonate 

Downstream Products

• 2366-74-7 1-tert-butyl-2-fluoro-3,5-dimethylbenzene 
• 327-95-7 4-fluorobenzene-1,3-dioic acid 
• 403-15-6 4-fluoro-3-methyl-benzoic acid 
• 389-34-4 2-(5-fluoro-2,4-dimethyl-benzoyl)-benzoic acid 
• 7571-87-1 2-(3-fluoro-2,6-dimethyl-benzoyl)-benzoic acid 
• 327-94-6 4-fluoro-isophthaloyl chloride 
• 453-66-7 4-fluoro-isophthalic acid bis-(2-diethylamino-ethyl ester); dihydrochloride 
• 497-60-9 4-fluoro-isophthalic acid bis-(2-dipropylamino-ethyl ester); dihydrochloride 
• 453-68-9 4-fluoro-isophthalic acid bis-(3-dipropylamino-propylester); dihydrochloride 
• 2966-58-7 4-fluoro-isophthalic acid bis-(2-dibutylamino-ethyl ester); dihydrochloride 
• 453-67-8 4-fluoro-isophthalic acid bis-(3-dibutylamino-propylester); dihydrochloride 

Relevant articles and documents

Fluorinations of unsymmetrical diaryliodonium salts containing: Ortho -sidearms; Influence of sidearm on selectivity

Activated aromatics were reacted with two different fluoroidoane reagents 1 and 2 in the presence of triflic acid to prepare only the para-substituted diaryliodonium salts. With fluoroiodane 1 the unsymmetrical diaryliodonium salts contained an ortho-propan-2-ol sidearm, whereas the alcohol sidearm was eliminated to form an ortho-styrene sidearm in the reaction with fluoroiodane 2. Only the diaryliodonium salts containing a styrene sidearm were fluorinated successfully to deliver para-fluorinated aromatics in good yields.

Mild copper-mediated fluorination of aryl stannanes and aryl trifluoroborates

This communication describes a mild copper-mediated fluorination of aryl stannanes and aryl trifluoroborates with N-fluoro-2,4,6-trimethylpyridinium triflate. This protocol demonstrates broad substrate scope and functional group tolerance, and does not require the use of any noble metal additives. The reaction is proposed to proceed via an arylcopper(III) fluoride intermediate.

Metal-Catalyzed Carbon-Fluorine Bond Formation

One aspect of the invention relates to a metal-catalyzed conversion of aryl halides and sulfonates to the corresponding aryl fluorides. Another aspect of the invention relates to a metal-catalyzed conversion of heteroaryl halides and sulfonates to the corresponding heteroaryl fluorides. Another aspect of the invention relates to a metal-catalyzed conversion of vinyl halides and sulfonates to the corresponding vinyl fluorides. In certain embodiments, simple fluoride sources, such as AgF and CsF, are used. In certain embodiments, the transformations tolerate a wide range of functional groups, allowing for introduction of fluorine atoms into highly functionalized organic molecules.