328087-65-6

Basic information

• Product Name: 4-amino-5-furan-2-yl-7-(2-hydroxy-phenyl)-1H-pyrido[2,3-d]pyrimidine-2-thione
• CAS NO: 328087-65-6
• Molecular Weight: 336.374
• Mol File: 328087-65-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-amino-5-furan-2-yl-7-(2-hydroxy-phenyl)-1H-pyrido[2,3-d]pyrimidine-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-5-furan-2-yl-7-(2-hydroxy-phenyl)-1H-pyrido[2,3-d]pyrimidine-2-thione(328087-65-6)
• EPA Substance Registry System: 4-amino-5-furan-2-yl-7-(2-hydroxy-phenyl)-1H-pyrido[2,3-d]pyrimidine-2-thione(328087-65-6)

Safety Data

• Hazardous Substances Data: 328087-65-6(Hazardous Substances Data)

Upstream product

• 2875-23-2 3-(furan-2-yl)-1-(2-hydroxyphenyl)propen-1-one 
• 17356-08-0 thiourea 
• 328087-61-2 2-amino-4-(furan-2-yl)-6-(2-hydroxyphenyl)nicotinonitrile 

Relevant articles and documents

Synthesis of some new pyrido[2,3-d]pyrimidines and their ribofuranosides as possible antimicrobial agents

The ribofuranosides, namely, 4-amino-5,7-disubstituted-1-[2′,3′,5′- tri-O-benzoyl-α-D-ribofuranosyl]pyrido-[2,3-d] pyrimidine-2(1H)-thiones, have been synthesized by the condensation of trimethylsilyl derivatives of 5,7-disubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate in the presence of SnCl4. The heterocyclic bases, namely, 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones, were synthesized by the treatment of 2-amino-3-cyano-4,6-disubstituted pyridines with thiourea. The structures of all the synthesized ribofuranosides and their precursors have been established by elemental analysis, IR, and 1H NMR spectral data. The 13C NMR data of ribofuranosides has also been presented. All the synthesized heterocyclic bases and their ribofuranosides have been screened for their antibacterial and antifungal activities.