328087-61-2

Basic information

• Product Name: 2-amino-4-(furan-2-yl)-6-(2-hydroxyphenyl)nicotinonitrile
• Synonyms: 2-amino-4-(furan-2-yl)-6-(2-hydroxyphenyl)nicotinonitrile
• CAS NO: 328087-61-2
• Molecular Weight: 277.282
• Mol File: 328087-61-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-amino-4-(furan-2-yl)-6-(2-hydroxyphenyl)nicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-(furan-2-yl)-6-(2-hydroxyphenyl)nicotinonitrile(328087-61-2)
• EPA Substance Registry System: 2-amino-4-(furan-2-yl)-6-(2-hydroxyphenyl)nicotinonitrile(328087-61-2)

Safety Data

• Hazardous Substances Data: 328087-61-2(Hazardous Substances Data)

Upstream product

• 109-77-3 malononitrile 
• 2875-23-2 3-(furan-2-yl)-1-(2-hydroxyphenyl)propen-1-one 
• 62737-71-7 2-cyano-3-methyl-3-(2-furyl)propenenitrile 
• 71730-46-6 benzo[e][1,2,3]oxathiazine 2,2-dioxide 

Downstream Products

• 328087-65-6 4-amino-5-furan-2-yl-7-(2-hydroxy-phenyl)-1H-pyrido[2,3-d]pyrimidine-2-thione 
• 329190-11-6 5-furan-2-yl-7-(2-hydroxy-phenyl)-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione 
• 400031-49-4 2-amino-4-furan-2-yl-6-(2-hydroxy-phenyl)-nicotinamide 
• 400031-78-9 5-furan-2-yl-7-(2-hydroxy-phenyl)-3-(2-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 

Relevant articles and documents

Cu(OAc)2/DABCO-mediated domino reaction of vinyl malononitriles with cyclic sulfamidate imines: access to 6-hydroxyaryl-2-aminonicotinonitriles

A novel Cu(ii)–salt/DABCO-mediated one-pot access to a myriad of highly substituted biologically relevant 2-aminonicotinonitriles possessing a resourceful phenolic moiety with satisfactory yields is reported. This method involves cyclic sulfamidate imines as 1C1N sources and different kinds of acyclic/cyclic vinyl malononitriles as 4C sources for pyridine synthesis via a vinylogous Mannich-cycloaromatization sequence process, creating two new C–N bonds under mild conditions. Importantly, this de novo strategy is applicable to gram-scale syntheses, underlining the method's practicability and allowing for a wide range of substrates with excellent functional group tolerance.

Synthesis of some new pyrido[2,3-d]pyrimidines and their ribofuranosides as possible antimicrobial agents

The ribofuranosides, namely, 4-amino-5,7-disubstituted-1-[2′,3′,5′- tri-O-benzoyl-α-D-ribofuranosyl]pyrido-[2,3-d] pyrimidine-2(1H)-thiones, have been synthesized by the condensation of trimethylsilyl derivatives of 5,7-disubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate in the presence of SnCl4. The heterocyclic bases, namely, 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones, were synthesized by the treatment of 2-amino-3-cyano-4,6-disubstituted pyridines with thiourea. The structures of all the synthesized ribofuranosides and their precursors have been established by elemental analysis, IR, and 1H NMR spectral data. The 13C NMR data of ribofuranosides has also been presented. All the synthesized heterocyclic bases and their ribofuranosides have been screened for their antibacterial and antifungal activities.

Synthesis of some novel 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones and their nucleosides as potential therapeutic agents

Some newer 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones were synthesized by the condensation of 2-amino-3-cyano-4,6-disubstituted pyridines with phenylisothiocyanate. The nucleosides viz., 4-imino-3,5,7-trisubstituted-1-(2,3,5-tri-O-