328554-54-7

Basic information

• Product Name: 2,6-dimethyl-4-(4-fluorophenylamino)-3-nitropyridine
• Synonyms: 2,6-dimethyl-4-(4-fluorophenylamino)-3-nitropyridine
• CAS NO: 328554-54-7
• Molecular Weight: 261.256
• Mol File: 328554-54-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-dimethyl-4-(4-fluorophenylamino)-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethyl-4-(4-fluorophenylamino)-3-nitropyridine(328554-54-7)
• EPA Substance Registry System: 2,6-dimethyl-4-(4-fluorophenylamino)-3-nitropyridine(328554-54-7)

Safety Data

• Hazardous Substances Data: 328554-54-7(Hazardous Substances Data)

Upstream product

• 13603-45-7 2,6-dimethyl-4-hydroxy-3-nitropyridine 
• 15513-48-1 4-chloro-2,6-dimethyl-3-nitropyridine 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 328554-55-8 3-amino-2,6-dimethyl-4-(4-fluorophenylamino)pyridine 

Relevant articles and documents

Synthesis and SAR of a new series of COX-2-selective inhibitors: Pyrazolo[1,5-α]pyrimidines

The synthesis and pharmacological activity of a series of bicyclic pyrazolo[1,5-α]pyrimidines as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The new compounds were evaluated both in vitro (COX-1 and COX-2 inhibition in human whole blood) and in vivo (carrageenan-induced paw edema and air-pouch model). Modification of the pyrimidine substituents showed that 6,7-disubstitution provided the best activity and led to the identification of 3-(4-fluorophenyl)-6,7-dimethyl-2-(4-methylsulfonylphenyl) pyrazolo[1,5-α]pyrimidine (10f) as one of the most potent and selective COX-2 inhibitor in this series.