329-78-2

Basic information

• Product Name: 1-(4-Chlorophenyl)-2-fluoroethanone
• Synonyms: 1-(4-chlorophenyl)-2-fluoroethanone;2-FLUORO-4'-CHLOROACETOPHENONE;4-CHLOROPHENACYLFLUORIDE;2-Chloro-4'-Fluoroacetophenone 4-Fluoro-alpha-Chloroacetophenone;4-Fluoro-α-chloroacetophenone;4-Fluoro-a-Chloroacetophenone;Ethanone, 1-(4-chlorophenyl)-2-fluoro- (9CI);4-Fluoro-a-chloroacetophenone/Fluorochloroacetophenone
• CAS NO: 329-78-2
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.58
• Product Categories: ACETYLHALIDE
• Mol File: 329-78-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 54 °C
• Boiling Point: 260.3 °C at 760 mmHg
• Flash Point: 111.2 °C
• Appearance: /
• Density: 1.247 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-(4-Chlorophenyl)-2-fluoroethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Chlorophenyl)-2-fluoroethanone(329-78-2)
• EPA Substance Registry System: 1-(4-Chlorophenyl)-2-fluoroethanone(329-78-2)

Safety Data

• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 1759
• Hazardous Substances Data: 329-78-2(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenyl)-2-fluoroethanone is a chemical compound with the molecular formula C8H7ClF. It belongs to the class of ketones and contains a phenyl ring with a chlorine substituent and a fluorine atom attached to the ethanone group. 1-(4-Chlorophenyl)-2-fluoroethanone is commonly used in organic synthesis and medicinal chemistry as a building block for the creation of various pharmaceuticals, agrochemicals, and other fine chemicals. It is important to handle this compound with proper care and follow all safety protocols due to its potential health hazards and reactivity.

Upstream product

• 359-06-8 monofluoroacetyl chloride 
• 108-90-7 chlorobenzene 
• 413598-38-6 [(E)-1-(4-Chloro-phenyl)-2-fluoro-vinyloxy]-trimethyl-silane 
• 914801-65-3 N-(1-(4-chlorophenyl)-2-fluoroethylidene)isopropylamine 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 
• 655-54-9 1-(4-chlorophenyl)-2,2-difluoropent-4-en-1-ol 
• 243845-56-9 2,2-difluoro-1-(4'-chloro-phenyl)-1-trimethylsiloxyethene 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 99-91-2 para-chloroacetophenone 
• 459-72-3 ethyl 2-fluoroacetate 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 1073-67-2 4-vinylbenzyl chloride 
• 331238-93-8 ADC₁₁₃ 
• 1354970-09-4 1-(1-azido-2-iodoethyl)-4-chlorobenzene 

Downstream Products

• 329-77-1 1-(4-chlorophenyl)-2-fluoroethanol 
• 1312213-34-5 2-(4-chlorophenyl)-3-fluoro-5,6,7,8-tetrahydro-4-phenyl-[1]benzothieno[2,3-b]pyridine 
• 1312213-29-8 2-(4-chlorophenyl)-3-fluoro-4-methylquinoline 
• 1312213-18-5 2-(4-chlorophenyl)-3-fluoro-4-phenylquinoline 
• 1415315-18-2 C₁₂H₁₄ClF 
• 1446417-86-2 1-(4-chlorophenyl)-2-fluoroethan-1-ol 
• 1261174-88-2 1-(4-chlorophenyl)-2-fluoroethan-1-ol 
• 99-91-2 para-chloroacetophenone 

Relevant articles and documents

A Carbene Strategy for Progressive (Deutero)Hydrodefluorination of Fluoroalkyl Ketones

Hydrodefluorination is one of the most promising chemical strategies to degrade perfluorochemicals into partially fluorinated compounds. However, controlled progressive hydrodefluorination remains a significant challenge, owing to the decrease in the stre

Α - fluoro acetophenone derivative

PROBLEM TO BE SOLVED: To provide a new production method of an α-fluoroacetophenone derivative by a simple one-step fluorination reaction with an acetophenone derivative under a mild condition.SOLUTION: An acetophenone derivative represented by formula (I) is reacted with a hydrogen fluoride/amine complex in the presence of a hypervalent iodine compound, (in the formula, a ring A indicates an aromatic ring of 1-3 members; Rindicates a hydrogen atom or an aromatic ring of 1-3 members that may be substituted; Rindicates a hydrogen atom or an alkyl group of 1-6 carbons; and Rindicates a hydrogen atom, an alkyl group of 1-6 carbons, an alkoxy group of 1-6 carbons or a halogen atom). The H part in formula (I) is substituted and fluorinated.

Synthesis of α-Fluoroketones from Vinyl Azides and Mechanism Interrogation

An efficient and mild fluorination of vinyl azides for the synthesis of α-fluoroketones is described. The mechanistic studies indicated that a single-electron transfer (SET) and a subsequent fluorine atom transfer process could be involved in the reaction.