329781-57-9

Basic information

• Product Name: Benzoic acid, 2-(azidomethyl)-, methyl ester
• CAS NO: 329781-57-9
• Molecular Formula: C9H9N3O2
• Molecular Weight: 191.189
• Mol File: 329781-57-9.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(azidomethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(azidomethyl)-, methyl ester(329781-57-9)
• EPA Substance Registry System: Benzoic acid, 2-(azidomethyl)-, methyl ester(329781-57-9)

Safety Data

• Hazardous Substances Data: 329781-57-9(Hazardous Substances Data)

Upstream product

• 933-88-0 ortho-toluoyl chloride 
• 118-90-1 ortho-methylbenzoic acid 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 87-41-2 2-benzofuran-1(3H)-one 
• 34040-62-5 o-(chloromethyl)benzoic acid methyl ester 
• 2417-73-4 methyl 2-bromomethylbenzoate 

Downstream Products

• 289712-57-8 2-(azidomethyl)benzoic acid 
• 289712-58-9 2-(azidomethyl)benzoyl chloride 
• 501432-17-3 2-Azidomethyl-benzoic acid (3aR,5S,6R,6aR)-2,2-dimethyl-5-(S)-thiiranyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 
• 501432-19-5 2-Azidomethyl-benzoic acid (2S,3R,4S,5S,6R)-2,3,5-trihydroxy-6-hydroxymethyl-tetrahydro-thiopyran-4-yl ester 
• 501432-20-8 2-Azidomethyl-benzoic acid (3aS,4aR,8aS,9S,9aR)-2,2,7,7-tetramethyl-hexahydro-[1,3]dioxolo[4',5':5,6]thiopyrano[3,2-d][1,3]dioxin-9-yl ester 
• 501432-18-4 2-Azidomethyl-benzoic acid (3aR,5S,6R,6aR)-5-((R)-2-acetoxy-1-acetylsulfanyl-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 
• 385422-26-4 6-O-(2-(azidomethyl)benzoyl)-3,4-di-O-benzyl-glucal 
• 385422-27-5 1,3,4,6-tetra-O-acetyl-2-O-(2-(azidomethyl)benzoyl)-α-D-galactopyranoside 
• 373606-22-5 methyl 6-O-(2-(azidomethyl)benzoyl)-3,4-di-O-benzyl-β-D-glucopyranoside 
• 385421-92-1 methyl 2-O-acetyl-6-O-(2-(azidomethyl)benzoyl)-3,4-di-O-benzyl-β-D-glucopyranoside 
• 385421-94-3 methyl 2-O-allyl-6-O-(2-(azidomethyl)benzoyl)-3,4-di-O-benzyl-β-D-glucopyranoside 
• 385422-06-0 3,4,6-tri-O-acetyl-2-O-(2-(azidomethyl)benzoyl)-α-D-galactopyranosyl trichloroacetimidate 
• 385421-93-2 methyl 6-O-(2-(azidomethyl)benzoyl)-3,4-di-O-benzyl-2-levulinyl-β-D-glucopyranoside 
• 385422-04-8 thioethyl 2-O-(2-(azidomethyl)benzoyl)-3,4,6-tri-O-benzyl-β-D-glucopyranoside 

Relevant articles and documents

Inverted positioning of dnmt1 inhibitor in the active site of dnmt1 caused by hydrophobicity/hydrophilicity of the terminal structure

DNA (cytosine-5)-methyltransferase 1 (DNMT1) is one of the enzymes that regulate DNA modification. It has been demonstrated that overexpression of DNMT1 is associated with the development of cancer, making DNMT1 an attractive molecular target for cancer t

Performance comparison of two cascade reaction models in fluorescence off-on detection of hydrogen sulfide

Comparative studies on the performances of two cascade reaction based fluorescent H2S probes are reported. These probes were also designed to address the solubility issues of existing probes. The Reso-N3 probe favors the H2S mediated azide-to-amine reduction followed by a cyclization to release the resorufin fluorophore. Reso-Br undergoes a bromide-to-thiol nucleophilic substitution followed by a similar cyclization releasing the same fluorophore. Reso-N3 exhibited lower background fluorescence and better H2S sensing behavior in water compared to Reso-Br. Reso-Br underwent hydrolysis in aqueous buffer conditions (pH = 7.4) while, Reso-N3 was quite stable. Reso-N3 displayed high selectivity and sensitivity towards H2S. Live cell imaging of the species by the probe was also established. This journal is

Expanding the structural repertoire of β/α Ant-Pro (anthranilic acid-proline) oligomers into γ/α 2-Amb-Pro (2-aminomethyl benzoic acid-proline) oligomers

In this article, we report a novel class of heterogeneous synthetic oligomers featuring the conformationally constrained amino acid residues - 2-aminomethyl benzoic acid (2-Amb) and proline (Pro) in repeating sequences. Oligomers as large as hexadecamers featuring the conformationally restricted γ/α 2-Amb-Pro motif have been assembled using solution-phase Boc strategy, following multi-step synthetic sequences starting from the commercially available O-toluic acid. EDC-mediated peptide coupling has been found to be optimum for the assembly of the relatively non-polar oligomers, which could be readily purified by the standard column chromatographic purification procedures. This study offers considerable prospects of expanding the structural repertoire of β/α Ant-Pro motif, which has been described earlier to assume right-handed helical architecture displaying robust nine-membered-ring closed network of hydrogen-bonding interactions, into γ/α 2-Amb-Pro motif.