33081-07-1

Basic information

• Product Name: 2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL
• Synonyms: BUTTPARK 15\02-44;2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL;2-AMINO-4-HYDROXY-5,6,7,8-TETRAHYDROQUINAZOLINE;2-AMINO-5,6,7,8-TETRAHYDRO-4-QUINAZOLINOL;2-amino-5,6,7,8-tetrahydro-4-quinazolinol(SALTDATA: FREE);2-AMino-5,6,7,8-tetrahydro-3H-quinazolin-4-one;2-Amino-5,6,7,8-tetrahydroquinazolin-4-ol, 4-Hydroxy-5,6,7,8-tetrahydroquinazolin-2-amine;Apollo Scientific OR8486
• CAS NO: 33081-07-1
• Molecular Formula: C8H11N3O
• Molecular Weight: 165.19
• Product Categories: pharmacetical
• Mol File: 33081-07-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 284-288 °C
• Boiling Point: 337.4°C at 760 mmHg
• Flash Point: 157.9°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 0.000105mmHg at 25°C
• Refractive Index: 1.734
• PKA: 3.00±0.20(Predicted)
• CAS DataBase Reference: 2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL(33081-07-1)
• EPA Substance Registry System: 2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL(33081-07-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 33081-07-1(Hazardous Substances Data)

Usage

General Description

2-Amino-5,6,7,8-tetrahydro-quinazolin-4-ol is a chemical compound with the molecular formula C9H12N2O. It is a quinazoline derivative and a potential intermediate in the synthesis of pharmaceutical compounds. 2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL has been studied for its potential applications in the development of new drugs for various medical conditions, including cancer, neurological disorders, and infectious diseases. Its structure and properties make it a promising candidate for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C8H11N3O/c9-8-10-6-4-2-1-3-5(6)7(12)11-8/h1-4H2,(H3,9,10,11,12)

Upstream product

• 506-93-4 guanidine nitrate 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 50-01-1 guanidine hydrochloride 
• 68965-62-8 2-bromocyclohex-1-enecarboxylic acid 
• 124-46-9 guanidine hydrogen carbonate 
• 41302-34-5 2-(methoxycarbonyl)cyclohexanone 

Downstream Products

• 111896-77-6 4-chloro-5,6,7,8-tetrahydroquinazoline-2-ylamine 

Relevant articles and documents

Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H 4 receptor antagonists

This report discloses the discovery and SAR of a series of 6-alkyl-2-aminopyrimidine derived histamine H4 antagonists that led to the development of JNJ 39758979, which has been studied in phase II clinical trials in asthma and atopic dermatitis. Building on our SAR studies of saturated derivatives from the indole carboxamide series, typified by JNJ 7777120, and incorporating knowledge from the tricyclic pyrimidines led us to the 6-alkyl-2,4-diaminopyrimidine series. A focused medicinal chemistry effort delivered several 6-alkyl-2,4-diaminopyrimidines that behaved as antagonists at both the human and rodent H4 receptor. Further optimization led to a panel of antagonists that were profiled in animal models of inflammatory disease. On the basis of the preclinical profile and efficacy in several animal models, JNJ 39758979 was selected as a clinical candidate; however, further development was halted during phase II because of the observation of drug-induced agranulocytosis (DIAG) in two subjects.

Bicyclic pyrimidine compounds and therapeutic use thereof

A pyrimidine derivative of the formula (1) or a salt thereof; has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.

Nonclassical 5-substituted tetrahydroquinazolines as potential inhibitors of thymidylate synthase

Classical inhibitors of thymidylate synthase such as N10-propargyl- 5,8-dideazafolic acid (1), N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6- ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic acid (ZD1694, 2) and N-[2- amino-4-oxo-3,4-dihydro(py