331646-98-1

Basic information

• Product Name: 8-BROMO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
• Synonyms: 3-BROMOISATOIC ANHYDRIDE;8-BROMO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE;REF DUPL: 3-Bromoisatoic anhydride;2H-3,1-Benzoxazine-2,4(1H)-dione, 8-bromo-;8-Bromoisatoic anhydride;8-broMo-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione;8-Bromo-2H-3,1-benzoxazine-2,4(1H)-dione, 8-Bromo-1H-benzo[d][1,3]oxazine-2,4-dione;8-bromo-1H-3,1-benzoxazine-2,4-dione
• CAS NO: 331646-98-1
• Molecular Formula: C₈H₄BrNO₃
• Molecular Weight: 242.03
• EINECS: 1533716-785-6
• Mol File: 331646-98-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.826 g/cm³
• Refractive Index: 1.622
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 8-BROMO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE(331646-98-1)
• EPA Substance Registry System: 8-BROMO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE(331646-98-1)

Safety Data

• Hazardous Substances Data: 331646-98-1(Hazardous Substances Data)

Usage

Preparation

3-Bromoisatoic anhydride is prepared from 7-bromo-3-carbaldehyde by stirring in a 4:1 mixture of CH3CN/H2O for 1 h at 40℃. 1 H NMR: δ11.08 (s, br., 1H), 8.02 (d, J = 7.8 Hz, 1H), 7.94 (d, J = 7.8 Hz, 1H), 7.19 (t, J = 7.8 Hz, 1H).

InChI:InChI=1/C8H4BrNO3/c9-5-3-1-2-4-6(5)10-8(12)13-7(4)11/h1-3H,(H,10,12)

Upstream product

• 115666-21-2 7-bromo-1 H-indole-3-carbaldehyde 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 20776-51-6 2-amino-3-bromo benzoic acid 
• 20780-74-9 7-bromoisatin 

Downstream Products

• 1332526-72-3 C₁₉H₁₉N₃S 
• 1332527-05-5 C₁₄H₁₁BrN₂S 
• 1332527-00-0 C₁₃H₉BrN₂O 
• 437998-34-0 2-amino-3-bromobenzamide 
• 1258630-85-1 2-amino-8-bromoquinazolin-4(3H)-one 

Relevant articles and documents

Discovery of evodiamine derivatives as potent insecticide candidates

In the search for novel more effective insecticides, natural products could be used as ideal template compounds due to their good environmental compatibility, various bioactivities, unique scaffolds and mode of action. We have found that natural product evodiamine, the main active component from the fruits of Evodia rutaecarpa (Juss.) Benth, displayed obvious insecticidal activities against lepidoptera pests. To continue our research, a series of evodiamine derivatives 3a-3aa were rationally designed and synthesized. The larvicidal activities results indicated that most of target compounds displayed better efficacy than evodiamine, matrine, and rotenone against Mythimna separata, Plutella xylostella and Helicoverpa armigera, among which 3z exhibited excellent larvicidal activities (65% at 2.5 mg/L against M. separata, 75% at 1.0 mg/L against P. xylostella, and 85% 10 mg/L against H. armigera, respectively), much better than evodiamine (0%), matrine (0%), and rotenone (0%). The preliminary structure activity relationships demonstrated that the fluorine atom at the E ring of evodiamine had a positive influence on the larvicidal activity. The calcium imaging experiment studies indicated that 3z could act on the ryanodine receptor (RyR) of M. separata and was an effective calcium activator for RyR.

Benzothiazole compound and its preparation method and as the application of the hypobromous acid probe

The invention benzothiazole compound probe and HBrO after reacting a cyclic sulfur imines key, so that the conjugate of increased levels of the reaction system, the reaction system of the fluorescence intensity of red shifted 137 nm, the ratio of the fluo

METALLO-BETA-LACTAMASE INHIBITORS

The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.