33167-21-4 Usage
Description
3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is an organic compound that serves as a versatile reagent and reactant in various chemical reactions and synthesis processes. It is characterized by its ability to participate in oxidative cross-coupling, chlorination, hydrosilylation, and other reactions, making it a valuable component in the fields of chemistry and pharmaceuticals.
Uses
Used in Chemical Synthesis:
3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a reagent/reactant for oxidative cross-coupling via dioxygen activation with indoles. This application allows for the formation of new chemical bonds and the creation of complex molecular structures.
Used in Pharmaceutical Industry:
3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a reactant in the chlorination and hydrosilylation process for the synthesis of α-hydroxy β-amino acid derivatives. These derivatives are essential building blocks in the development of various pharmaceutical compounds.
Used in Chiral Lewis Base-Catalyzed Reduction:
3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER serves as a precursor for substrates in chiral Lewis base-catalyzed stereoselective reduction with trichlorosilane and water. This application is crucial for obtaining specific enantiomers, which are important in the pharmaceutical industry for their targeted therapeutic effects.
Used in Organic Synthesis:
3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a reactant in intramolecular cyclization reactions for the synthesis of dihydrofurans. These cyclic compounds are valuable intermediates in the synthesis of various organic molecules and natural products.
Used in Accelerating Reactions:
3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a reactant to rate-accelerate Michael reactions, which are essential in the formation of carbon-carbon double bonds in various organic compounds.
Used in Oxidative Coupling:
3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a reactant in cerium ammonium nitrate-mediated oxidative coupling reactions. This application is vital for the formation of new carbon-carbon bonds and the synthesis of complex organic molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 33167-21-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,1,6 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 33167-21:
(7*3)+(6*3)+(5*1)+(4*6)+(3*7)+(2*2)+(1*1)=94
94 % 10 = 4
So 33167-21-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H11ClO3/c1-2-15-11(14)7-10(13)8-4-3-5-9(12)6-8/h3-6H,2,7H2,1H3
33167-21-4Relevant articles and documents
Electrochemical Oxidative Cyclization: Synthesis of Polysubstituted Pyrrole from Enamines
Chen, Zhiwei,Shi, Guang,Tang, Wei,Sun, Jie,Wang, Wenxing
supporting information, p. 951 - 955 (2021/02/03)
A conceptually novel method for the preparation of pyrrole is described by electrochemical-oxidation-induced intermolecular annulation via enamines. In a simple undivided cell, based on a sodium acetate-facilitated, polysubstituted pyrrole derivations has been facilely synthesized under external oxidant-free condition. This electrosynthetic approach providing an environmentally benign protocol for C?C bond cross-coupling and oxidative annulation, which features unparalleled broad scope of substrates and practicality.
Phosphoryl N - fatty acyl nucleoside analogues for treatment of viral hepatitis and liver cancer
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Paragraph 0033-0036, (2020/07/13)
The invention discloses a phosphoryl N-fatty acyl nucleoside analogue for treating viral hepatitis and liver cancer. The phosphoryl N-fatty acyl nucleoside analogue is characterized in that a nucleoside analogue is modified by a cyclophosphoryl group and
Double Enzyme-Catalyzed One-Pot Synthesis of Enantiocomplementary Vicinal Fluoro Alcohols
Fan, Jiajie,Lin, Xianfu,Peng, Yongzhen,Wang, Anlin,Wu, Qi,Xu, Jian,Xu, Weihua,Yu, Huilei
supporting information, (2020/07/24)
A double-enzyme-catalyzed strategy for the synthesis of enantiocomplementary vicinal fluoro alcohols through a one-pot, three-step process including lipase-catalyzed hydrolysis, spontaneous decarboxylative fluorination, and subsequent ketoreductase-catalyzed reduction was developed. With this approach, β-ketonic esters were converted to the corresponding vicinal fluoro alcohols with high isolated yields (up to 92percent) and stereoselectivities (up to 99percent). This new cascade process addresses some issues in comparison with traditional methods such as environmentally hazardous reaction conditions and low stereoselectivity outcome.
