33208-99-0Relevant articles and documents
Amino acid amide hydrochloride without inorganic ammonium salt and synthesis method thereof
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Paragraph 0036-0042, (2022/01/10)
The present invention discloses an amino acidamide hydrochloride without inorganic ammonium salts and a synthesis method thereof, comprising the following steps: S1, the amino acid under alkaline conditions, added di-tert-butyl dicarbonate to prepare tert-butoxycarbonyl - amino acid; S2, to the prepared tert-butoxycarbonyl - amino acid and then add di-tert-butyl dicarbonate, in the presence of N- methyl morpholine, ammonium bicarbonate, the preparation of tert-butoxycarbonyl - amino acid amide; S3, the tert-butoxycarbonyl - amino acid amide placed in the ethyl acetate / hydrogen chloride solution system, Crystallization is obtained immediately. The present invention is twice added di-tert-butyl dicarbonate, prepared under different conditions to give a high purity tert-butoxycarbonyl - amino acid amide, and finally in the ethyl acetate / hydrogen chloride solution conditions to obtain the final product, the present invention solves the problem of inorganic ammonium salts in the production of amino acid amide hydrochloride difficult to separate, reducing the amount of organic solvent.
BICYCLIC COMPOUNDS
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Paragraph 00727, (2020/06/01)
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.
Thermodynamic and Structural Investigation of Synthetic Actinide-Peptide Scaffolds
Safi, Samir,Jeanson, Aurélie,Roques, Jérome,Solari, Pier Lorenzo,Charnay-Pouget, Florence,Den Auwer, Christophe,Creff, Ga?lle,Aitken, David J.,Simoni, Eric
supporting information, p. 877 - 886 (2016/02/03)
The complexation of uranium and europium, in oxidation states +VI and +III, respectively, was investigated with pertinent bio-inorganic systems. Three aspartate-rich pentapeptides with different structural properties were selected for study to rationalize the structure-affinity relationships. Thermodynamic results, crosschecked by both isothermal titration calorimetry and time-resolved laser fluorescence spectroscopy, showed different affinity depending on the peptide for both Eu(III) and U(VI). The thermodynamic aspects were correlated to structural predictions, which were acquired by density functional theory quantum chemical calculations and from IR and extended X-ray absorption fine structure experiments. The combination of these microscopic properties revealed that carbonyl-metal interactions affected the entropy in the case of europium, while the larger uranyl cation was mostly affected by preorganization and steric effects, so that the affinity was enhanced through enthalpy. The approach described here revealed various microscopic aspects governing peptide actinide affinity. Highlighting these mechanisms should certainly contribute to the rational synthesis of higher affinity biomimetic aspartic ligands.