33388-67-9

Basic information

• Product Name: (2-methylphenyl)(piperidin-1-yl)methanone
• Synonyms: Piperidine, 1-(methylbenzoyl)-
• CAS NO: 33388-67-9
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.2802
• Mol File: 33388-67-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 347.2°C at 760 mmHg
• Flash Point: 158.5°C
• Density: 1.065g/cm³
• Vapor Pressure: 5.46E-05mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: (2-methylphenyl)(piperidin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methylphenyl)(piperidin-1-yl)methanone(33388-67-9)
• EPA Substance Registry System: (2-methylphenyl)(piperidin-1-yl)methanone(33388-67-9)

Safety Data

• Hazardous Substances Data: 33388-67-9(Hazardous Substances Data)

Usage

Description

(2-methylphenyl)(piperidin-1-yl)methanone, also known as MDPK, is a synthetic stimulant and substituted cathinone that belongs to the class of psychoactive designer drugs. It is a white crystalline powder that is commonly used as a recreational drug for its stimulating and euphoric effects. MDPK acts as a norepinephrine-dopamine reuptake inhibitor, leading to increased levels of these neurotransmitters in the brain. This results in heightened alertness, increased energy, and feelings of pleasure and euphoria.

Uses

Used in Recreational Drug Industry:
MDPK is used as a recreational drug for its stimulating and euphoric effects. It is often used as a substitute for other illegal stimulants, such as amphetamines or MDMA, due to its similar effects on the brain.
However, it is important to note that MDPK has been associated with adverse health effects, including cardiovascular complications and psychosis. As a result, it is considered a controlled substance in many countries.

Upstream product

• 110-89-4 piperidine 
• 105223-37-8 C₁₆H₁₄O₂Se₂ 
• 306743-67-9 4-acetophenyl 2-methylbenzoate 
• 74738-56-0 4-nitrophenyl 2-methylbenzoate 
• 95-46-5 2-methylphenyl bromide 
• 1009-01-4 2-methylphenyl methanesulfonate 
• 13939-06-5 molybdenum hexacarbonyl 
• 2591-86-8 N-Formylpiperidine 
• 529-20-4 2-methylphenyl aldehyde 
• 2156-71-0 N-chloropiperidine 
• 89-95-2 2-methyl-benzyl alcohol 
• 201230-82-2 carbon monoxide 
• 933-88-0 ortho-toluoyl chloride 
• 51180-63-3 1-methyl-2-(piperidin-1-ylmethyl)benzene 

Downstream Products

• 84538-49-8 2-(piperidine-1-carbonyl)benzaldehyde 
• 51180-63-3 1-methyl-2-(piperidin-1-ylmethyl)benzene 
• 529-20-4 2-methylphenyl aldehyde 

Relevant articles and documents

METHODS OF CONTROLLING CROP PESTS USING AROMATIC AMIDE INSECT REPELLENTS, METHODS OF MAKING AROMATIC AMIDE INSECT REPELLENTS, AND NOVEL AROMATIC AMIDE INSECT REPELLENTS

Methods of protecting fruit crops from flying insect pests and of repelling flying insects using aromatic amide compounds are disclosed. The methods apply the compounds to various surfaces, such as the fruit crops, the ground or structures adjacent to the fruit crops, or an object, article, human skin or animal. The compounds have the formula RxC6Hy—C(═O)—N(Cy), where RxC6Hy is a substituted phenyl group, each R group is independently C1-C6 alkyl, substituted C1-C4 alkyl, (substituted) C6-C10 aryl, C1-C4 alkoxy, C6-C10 aryloxy, halogen, nitro, cyano, cyanate, isocyanate, nitroso, C1-C4 alkylthio, phenylthio, (halogen-substituted) C1-C4 alkylsulfonyl, phenylsulfonyl, tolylsulfonyl, amino, mono- or di-C1-C4 alkylamino, diphenylamino, di-C1-C4 alkylamido, formyl, C2-C7 acyl, or C1-C6 alkoxycarbonyl; x is an integer of 1 to 5; x+y=5; Cy is a C2-C8 (substituted) alkadiyl, a C4-C6 (substituted) alkenediyl, or a (substituted) diyl of the formula —(CH2CH2)—O—(CH2CH2)—, —(CH2CH2)—NR′—(CH2CH2)— or —(CH2CH2)—S—(CH2CH2)— that, along with the amide N atom, forms a non-aromatic cyclic group; and R′ is C1-C6 alkyl, substituted C1-C4 alkyl, (substituted) C6-C10 aryl, or (substituted) benzyl.

Cobalt-catalyzed aminocarbonylation of (hetero)aryl halides promoted by visible light

The catalytic aminocarbonylation of (hetero)aryl halides is widely applied in the synthesis of amides but relies heavily on the use of precious metal catalysis. Herein, we report an aminocarbonylation of (hetero)aryl halides using a simple cobalt catalyst under visible light irradiation. The reaction extends to the use of (hetero)aryl chlorides and is successful with a broad range of amine nucleophiles. Mechanistic investigations are consistent with a reaction proceeding via intermolecular charge transfer involving a donor-acceptor complex of the substrate and cobaltate catalyst.

1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane: An efficient and high oxygen content oxidant in various oxidative reactions

Several oxidative approaches namely thiocyanation of aromatic compounds, epoxidation of alkenes, amidation of aromatic aldehydes, epoxidation of α β-unsaturated ketones, oxidation of sulfides to sulfoxides and sulfones, bayer-villeger reaction, bromination and iodation of aniline and phenol derivatives oxidative esterification, oxidation of pyridines and oxidation of secondary, allylic and benzyllic alcohols were carried out using 1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane as the potential solid oxidant which can be stored for several months without any loss in its activity. All of the procedures were accomplished via mild reaction conditions and the products were afforded in high yields and short reaction times.