3344-70-5Relevant articles and documents
Electrostatic Control of Macrocyclization Reactions within Nanospaces
Wang, Kaiya,Cai, Xiaoyang,Yao, Wei,Tang, Du,Kataria, Rhea,Ashbaugh, Henry S.,Byers, Larry D,Gibb, Bruce C.
supporting information, p. 6740 - 6747 (2019/05/06)
The intrinsic structural complexity of proteins makes it hard to identify the contributions of each noncovalent interaction behind the remarkable rate accelerations of enzymes. Coulombic forces are evidently primary, but despite developments in artificial nanoreactor design, a picture of the extent to which these can contribute has not been forthcoming. Here we report on two supramolecular capsules that possess structurally identical inner-spaces that differ in the electrostatic potential (EP) field that envelops them: one positive and one negative. This architecture means that only changes in the EP field influence the chemical properties of encapsulated species. We quantify these influences via acidity and rates of cyclization measurements for encapsulated guests, and we confirm the primary role of Coulombic forces with a simple mathematical model approximating the capsules as Born spheres within a continuum dielectric. These results reveal the reaction rate accelerations possible under Coulombic control and highlight important design criteria for nanoreactors.
A photoirradiative phase-vanishing method: Efficient generation of HBr from alkanes and molecular bromine and its use for subsequent radical addition to terminal alkenes
Matsubara, Hiroshi,Tsukida, Masaaki,Ishihara, Daisuke,Kuniyoshi, Kenji,Ryu, Ilhyong
experimental part, p. 2014 - 2018 (2010/10/02)
A triphasic phase-vanishing (PV) system comprised of an alkane, perfluorohexanes, and bromine was successfully combined by photoirradiation to efficiently generate hydrogen bromide, which underwent radical addition with 1-alkenes in the hydrocarbon layer to afford terminal bromides in high yields. Georg Thieme Verlag Stuttgart.
Effect of cyclohexenonic long chain fatty alcohols on neurite outgrowth. Study on structure-activity relationship
Girlanda-Junges, Celine,Keyling-Bilger, Florence,Schmitt, Gaby,Luu, Bang
, p. 7735 - 7748 (2007/10/03)
Four series of long chain fatty alcohols bearing a cyclohexenone moiety in addition to a ω-alkanol side chain were synthesized using 'Umpolung' reactivity strategy. Their effect on neurite outgrowth was evaluated by means of fetal rat neurons in culture. The length of the ω-hydroxy side chain is a crucial factor for biological activity.
