334477-60-0

Basic information

• Product Name: (R)-N-Methyl-1-[3,5-bis(trifluoromethyl)phenyl]ethylamine
• Synonyms: R-NME-MBT-PEM;(R)-N-METHYL-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;(R)-N-METHYL-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]-N-methylethanamine;(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]-N-methylethylamine;(R)-3,5-Bis(trifluoromethyl)-alpha,N-dimethylbenzylamine;(R)-1-(3,5-bis(trifluoromethyl)phenyl)-N-methylethanamine;Benzenemethanamine, N,a-dimethyl-3,5-bis(trifluoromethyl)-,(aR)-
• CAS NO: 334477-60-0
• Molecular Formula: C₁₁H₁₁F₆N
• Molecular Weight: 271.2
• EINECS: 251-528-5
• Mol File: 334477-60-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 172.9 °C at 760 mmHg
• Flash Point: 58.4 °C
• Appearance: /
• Density: 1.259 g/cm³
• Vapor Pressure: 1.3mmHg at 25°C
• Refractive Index: 1.415
• PKA: 8.93±0.10(Predicted)
• CAS DataBase Reference: (R)-N-Methyl-1-[3,5-bis(trifluoromethyl)phenyl]ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-Methyl-1-[3,5-bis(trifluoromethyl)phenyl]ethylamine(334477-60-0)
• EPA Substance Registry System: (R)-N-Methyl-1-[3,5-bis(trifluoromethyl)phenyl]ethylamine(334477-60-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 334477-60-0(Hazardous Substances Data)

Usage

General Description

(R)-N-Methyl-1-[3,5-bis(trifluoromethyl)phenyl]ethylamine is a chemical compound that is classified as an amine. It consists of a methyl group, a phenyl ring with two trifluoromethyl groups substituted at the 3 and 5 positions, and an ethylamine functional group. (R)-N-Methyl-1-[3,5-bis(trifluoromethyl)phenyl]ethylamine is often used in the pharmaceutical industry as an intermediate in the synthesis of various drugs, including antidepressants and antipsychotic medications. It is also used as a building block in organic synthesis for the creation of more complex molecules. In addition, this compound has potential applications in research and development for the study of organic chemistry, medicinal chemistry, and drug discovery.

InChI:InChI=1/C11H11F6N/c1-6(18-2)7-3-8(10(12,13)14)5-9(4-7)11(15,16)17/h3-6,18H,1-2H3/t6-/m1/s1

Upstream product

• 672907-02-7 C₁₉H₁₉F₆N 
• 737786-85-5 1-(3,5-bis(trifluoromethyl)phenyl)ethyl methanesulfonate 
• 74-89-5 methylamine 
• 935534-56-8 (R)-3,5-bis(trifluoromethyl)-α-methyl-N-methylbenzylamine L-(-)-malic acid salt 
• 672906-99-9 C₁₉H₁₉F₆N 
• 1000614-08-3 (R)-1-(3,5-bis(trifluoromethyl)phenyl)-N-methylethanamine p-toluenesulfonate 
• 1333317-70-6 (R)-N-(1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-N-methylacetamide 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 1333317-69-3 N-(1-(3,5-bis(trifluoromethyl) phenyl)ethylidene)methanamine 
• 895521-36-5 [(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl](methyl)amine L-malate 

Downstream Products

• 414910-03-5 (2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide 
• 645378-98-9 1,1-dimethylethyl-4-[3-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(2,4-dichlorophenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 645379-00-6 1,1-dimethylethyl-4-[3-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(2,4-dichlorophenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 645379-08-4 1,1-dimethylethyl-4-[3-[{(1R)-1-[3, 5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 645379-10-8 1,1-dimethylethyl-4-[3-[{(1R)-1-[3, 5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 645379-58-4 1,1-dimethylethyl-4-[3-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluorophenyl)-3-oxopropylidene]-1-piperidinecarboxylate 
• 645379-65-3 1,1-dimethylethyl-4-[3[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 645379-66-4 1,1-dimethylethyl-4-[3[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 645378-53-6 1,1-dimethylethyl-4-[3-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate 
• 645378-52-5 1,1-dimethylethyl-4-[3-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate 
• 645378-69-4 1,1-dimethylethyl-4-[3-[{(1R)-1-[3, 5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluorophenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 645378-71-8 1,1-dimethylethyl-4-[3-[{(1R)-1-[3, 5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluorophenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 644982-41-2 1,1-dimethylethyl 4-{2-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-2-oxoethyl}-4-(4-fluoro-2-methylphenyl)-1-piperidinecarboxylate 
• 1000614-08-3 (R)-1-(3,5-bis(trifluoromethyl)phenyl)-N-methylethanamine p-toluenesulfonate 

Relevant articles and documents

NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS

The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(=O)OR7 or C1-4 alkyl optionally substituted with hyd

Process for the production of chiral amines

The invention relates to a process for the preparation of optically active N-protected secondary amines by asymmetric hydrogenation in the presence of an optically active transition metal catalyst, one or more ligands, a nitrogen protecting reagent and optionally an additive, wherein the substrate is an imine.

METHOD FOR PRODUCING OPTICALLY ACTIVE BENZYLAMINE DERIVATIVE

Disclosed is a method for producing an optically active benzylamine derivative which is useful as an intermediate for pharmaceutical products and the like. Specifically, an optically active benzylsulfonylamide derivative as a novel compound is obtained by