33646-18-3

Basic information

• Product Name: 2-(3-OXO-CYCLOHEXYL)-MALONIC ACID DIMETHYL ESTER
• Synonyms: 2-(3-OXO-CYCLOHEXYL)-MALONIC ACID DIMETHYL ESTER
• CAS NO: 33646-18-3
• Molecular Formula: C₁₁H₁₆O₅
• Molecular Weight: 228.24174
• Mol File: 33646-18-3.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 306.5°Cat760mmHg
• Flash Point: 132°C
• Appearance: /
• Density: 1.17g/cm³
• CAS DataBase Reference: 2-(3-OXO-CYCLOHEXYL)-MALONIC ACID DIMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-OXO-CYCLOHEXYL)-MALONIC ACID DIMETHYL ESTER(33646-18-3)
• EPA Substance Registry System: 2-(3-OXO-CYCLOHEXYL)-MALONIC ACID DIMETHYL ESTER(33646-18-3)

Safety Data

• Hazardous Substances Data: 33646-18-3(Hazardous Substances Data)

Usage

Physical state

White to off-white solid

Common uses

Building block for the preparation of various organic compounds

Applications

Precursor in the production of pharmaceuticals, agrochemicals, and other fine chemicals

Role in research and development

Used for the creation of new chemical compounds

Functional group

Dimethyl ester group

Utility in organic reactions

Versatile and valuable reagent for carrying out a variety of organic reactions.

Upstream product

• 930-68-7 cyclohexenone 
• 108-59-8 malonic acid dimethyl ester 
• 186581-53-3 diazomethane 
• 855753-38-7 (3-oxocyclohexyl)malonic acid 
• 105-53-3 diethyl malonate 
• 847151-91-1 2-(3-oxocyclohexyl)malonic acid di-tert-butyl ester 

Downstream Products

• 2808-12-0 (cyclohexanone yl-3) acatate de methyle 
• 886587-78-6 2-{3-[bis-(4-hydroxy-phenyl)-methylene]-cyclohexyl}-malonic acid dimethyl ester 
• 855753-38-7 (3-oxocyclohexyl)malonic acid 
• 943448-05-3 C₁₄H₂₈O₂Si 
• 943448-06-4 C₁₇H₃₆O₂Si₂ 
• 943448-07-5 5-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-cyclohex-2-en-1-one 
• 5502-11-4 30(2-hydroxyethyl)-1-cyclohexanone 
• 886587-81-1 {3-[bis-(4-hydroxy-phenyl)-methylene]-cyclohexyl}-acetic acid methyl ester 
• 886587-86-6 3-(2-hydroxyethyl)[bis(4-methoxymethoxyphenyl)methylene]cyclohexane 
• 886587-97-9 3-(2-fluoroethyl)[bis(4-methoxymethoxyphenyl)methylene]cyclohexane 
• 886587-80-0 2-{3-[bis(4-hydroxyphenyl)methylene]cyclohexyl}malonic acid 
• 886587-83-3 methyl 2-{3-[bis(4-methoxymethoxyphenyl)methylene]cyclohexyl}acetate 
• 886587-91-3 3-(2-methanesulfonyloxyethyl)[bis(4-methoxymethoxyphenyl)methylene]cyclohexane 
• 1602829-47-9 dimethyl 2-(4-bromobut-2-yn-1-yl)-2-(3-oxocyclohexyl)malonate 

Relevant articles and documents

Effective Heterogeneous MoOx-Modified CeO2 Catalyst for Michael Addition of Dimethyl Malonate to 2-Cyclohexen-1-one

Molybdenum oxide-modified cerium oxide (MoOx?CeO2) with 1 wt % Mo acted as an effective and reusable heterogeneous catalyst for Michael addition of dimethyl malonate to 2-cyclohexen-1-one, providing high yield of the target product (

CpTiCl2-Catalyzed Cross-Coupling between Internal Alkynes and Ketones: A Novel Concept in the Synthesis of Halogenated, Conjugated Dienes

A novel concept for the synthesis of halogenated, conjugated dienes is disclosed: the CpTiCl2-catalyzed coupling of keto-alkynes, in the presence of Me3SiBr/Et3N?HBr. This reaction provided five-, six-, and seven-membered

A kind of T-leucine derivative of the chiral amine compound and its preparation method and application

The invention discloses a tertiary leucine derived chiral amine compound as well as a preparation method and application thereof. The chiral amine compound contains a tert-butyl group, a primary amine, a secondary amine or a tertiary amine functional group and has the structural formula as shown in the specification; and chiral amine and salts thereof are prepared through simple preparation steps by taking common tert-leucine as the raw material to form the chiral amine compound. The chiral amine and the salts thereof can be used for the asymmetrical Michael additive reaction between alpha, beta-unsaturated ketone and a nucleophilic reagent such as nitrocarbol, malonic ester, substituted oxazolone and the like and the asymmetrical cascade reaction between the alpha, beta-unsaturated ketone and fifth-position unsaturated rhodanine, between fifth-position unsaturated hydantoin and the alpha, beta-unsaturated ketone; and the tertiary leucine derived chiral amine compound has very high catalytic activity and stereoselectivity as well as the highest diastereoselectivity of 30/1 and the highest enantioselectivity of 99%, and is wide in oligomer range.