3371-56-0

Basic information

• Product Name: 17-Methyl-4,5α-epoxy-7,8-didehydromorphinan-3,6α,14-triol
• Synonyms: (5R,6S)-17-Methyl-7,8-didehydro-4,5-epoxymorphinan-3,6,14-triol;(5R,6S)-7,8-Didehydro-4,5α-epoxy-17-methylmorphinan-3,6α,14-triol;14-Hydroxymorphine;17-Methyl-4,5α-epoxy-7,8-didehydromorphinan-3,6α,14-triol
• CAS NO: 3371-56-0
• Molecular Formula: C₁₇H₁₉NO₄
• Molecular Weight: 301.3371
• Mol File: 3371-56-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 523.9°Cat760mmHg
• Flash Point: 270.6°C
• Appearance: /
• Density: 1.54g/cm³
• Vapor Pressure: 8.36E-12mmHg at 25°C
• Refractive Index: 1.752
• CAS DataBase Reference: 17-Methyl-4,5α-epoxy-7,8-didehydromorphinan-3,6α,14-triol(CAS DataBase Reference)
• NIST Chemistry Reference: 17-Methyl-4,5α-epoxy-7,8-didehydromorphinan-3,6α,14-triol(3371-56-0)
• EPA Substance Registry System: 17-Methyl-4,5α-epoxy-7,8-didehydromorphinan-3,6α,14-triol(3371-56-0)

Safety Data

• Hazardous Substances Data: 3371-56-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-5,11-12,15,19-21H,6-8H2,1H3/t11-,12+,15-,16-,17+/m0/s1

Upstream product

• 57-27-2 MORPHIN 
• 41135-98-2 14-hydroxymorphinone 
• 508-54-3 14-hydroxycodeinone 
• 115-37-7 thebaine 

Downstream Products

• 862190-33-8 6-O-tosyl-14-hydroxy-3-deoxymorphine 

Relevant articles and documents

Synthesis of 2-fluoro-11-hydroxy-N-propylnoraporphine: A potential dopamine D2 agonist

(Chemical Equation Presented) 2-Fluoro-11-hydroxy-N-propylnoraporphine 4 (2-F-11 -OH-NPa) was synthesized from thebaine in 13 steps with an overall yield of 1.35%. The key steps included the Pd-catalyzed 3-dehydroxylation of 14-hydroxymorphine, SN2 substitution of Ts- by F -, and CH3SO2OH-promoted rearrangement of the substituted morphinandiene. The dopamine binding affinity of this compound was also investigated on rat brain membranes, and as expected, this compound displayed high affinity and selectivity at the D2 receptor.