3389-54-6

Basic information

• Product Name: 1-BENZOYLPYRROLIDINE
• Synonyms: 1-BENZOYLPYRROLIDINE;(Pyrrolizino)(phenyl)methanone;Pyrrolizinophenyl ketone
• CAS NO: 3389-54-6
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol File: 3389-54-6.mol
• Article Data: 229

Chemical Properties

• Melting Point: 102 °C
• Boiling Point: 191-193 °C(Press: 12 Torr)
• Appearance: /
• Density: 1.117±0.06 g/cm3(Predicted)
• PKA: -1.14±0.20(Predicted)
• CAS DataBase Reference: 1-BENZOYLPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZOYLPYRROLIDINE(3389-54-6)
• EPA Substance Registry System: 1-BENZOYLPYRROLIDINE(3389-54-6)

Safety Data

• Hazardous Substances Data: 3389-54-6(Hazardous Substances Data)

Usage

General Description

1-Benzoylpyrrolidine, also known as N-benzoylpyrrolidine or N-phenylpyrrolidin-2-one, is a chemical compound with the molecular formula C12H11NO. It is a white to off-white solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. 1-Benzoylpyrrolidine is also known to exhibit psychoactive effects and is considered to be a designer drug, with its potential for abuse and addiction. 1-BENZOYLPYRROLIDINE has been regulated in various jurisdictions due to its psychoactive properties and potential for misuse. It is important to handle 1-benzoylpyrrolidine with caution and in accordance with safety guidelines to minimize potential hazards.

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Relevant articles and documents

Direct synthesis of N-acylpyrrolidines from tetrahydrofuran and nitriles of aliphatic and aromatic acids on zeolite catalysts under supercritical conditions

The tetrahydrofuran-nitrile (CH3CN, n-C4H 9CN, C6H5CN)-zeolite (faujasites, mordenite, beta, pentasils) system and its transformations under supercritical conditions were studied. The feasibility of d

One-Pot Synthesis of Tertiary Amides from Organic Trichlorides through Oxygen Atom Incorporation from Air by Convergent Paired Electrolysis

A convergent paired electrolysis catalyzed by a B12 complex for the one-pot synthesis of a tertiary amide from organic trichlorides (R-CCl3) has been developed. Various readily available organic trichlorides, such as benzotrichloride and its derivatives, chloroform, dichlorodiphenyltrichloroethane (DDT), trichloro-2,2,2-trifluoroethane (CFC-113a), and trichloroacetonitrile (CNCCl3), were converted to amides in the presence of tertiary amines through oxygen incorporation from air at room temperature. The amide formation mechanism in the paired electrolysis, which was mediated by a cobalt complex, was proposed.

A CO2-Catalyzed Transamidation Reaction

Transamidation reactions are often mediated by reactive substrates in the presence of overstoichiometric activating reagents and/or transition metal catalysts. Here we report the use of CO2as a traceless catalyst: in the presence of catalytic amounts of CO2, transamidation reactions were accelerated with primary, secondary, and tertiary amide donors. Various amine nucleophiles including amino acid derivatives were tolerated, showcasing the utility of transamidation in peptide modification and polymer degradation (e.g., Nylon-6,6). In particular,N,O-dimethylhydroxyl amides (Weinreb amides) displayed a distinct reactivity in the CO2-catalyzed transamidation versus a N2atmosphere. Comparative Hammett studies and kinetic analysis were conducted to elucidate the catalytic activation mechanism of molecular CO2, which was supported by DFT calculations. We attributed the positive effect of CO2in the transamidation reaction to the stabilization of tetrahedral intermediates by covalent binding to the electrophilic CO2