340026-88-2

Basic information

• Product Name: Diethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(formyl-methyl-amino)-ethyl ester
• Synonyms: Diethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(formyl-methyl-amino)-ethyl ester
• CAS NO: 340026-88-2
• Molecular Weight: 748.813
• Mol File: 340026-88-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Diethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(formyl-methyl-amino)-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(formyl-methyl-amino)-ethyl ester(340026-88-2)
• EPA Substance Registry System: Diethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(formyl-methyl-amino)-ethyl ester(340026-88-2)

Safety Data

• Hazardous Substances Data: 340026-88-2(Hazardous Substances Data)

Upstream product

• 2622-07-3 hexaethylphosphorous triamide 
• 1590-50-7 N-(2-hydroxyethyl)-N-methylformamide 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 

Relevant articles and documents

The 2-(N-formyl-N-methyl)aminoethyl group as a potential phosphate/thiophosphate protecting group in solid-phase oligodeoxyribonucleotide synthesis

(equation presented) The 2-(N-formyl-N-methyl)aminoethyl deoxyribonucleoside phosphoramidite 1 has been synthesized and used in the solid-phase synthesis of an octadecathymidylic acid as a cost-efficient monomer for potential application in the preparation of therapeutic oligonucleotides. The 2-(N-formyl-N-methyl)aminoethyl group can be cleaved from oligonucleotides according to a unique thermolytic cyclodeesterification process at pH 7.0. In addition to being cost-effective, the use of 1 simplifies oligonucleotide postsynthesis processing by eliminating the utilization of concentrated ammonium hydroxide in oligonucleotide deprotection.