1590-50-7

Basic information

• Product Name: N-(2-hydroxyethyl)-N-methylformamide
• Synonyms: N-(2-hydroxyethyl)-N-methylformamide
• CAS NO: 1590-50-7
• Molecular Formula: C₄H₉NO₂
• Molecular Weight: 103.11976
• EINECS: 216-463-9
• Mol File: 1590-50-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 282.2°Cat760mmHg
• Flash Point: 124.5°C
• Appearance: /
• Density: 1.067g/cm³
• Vapor Pressure: 0.000402mmHg at 25°C
• Refractive Index: 1.451
• PKA: 14.42±0.10(Predicted)
• CAS DataBase Reference: N-(2-hydroxyethyl)-N-methylformamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxyethyl)-N-methylformamide(1590-50-7)
• EPA Substance Registry System: N-(2-hydroxyethyl)-N-methylformamide(1590-50-7)

Safety Data

• Hazardous Substances Data: 1590-50-7(Hazardous Substances Data)

Usage

General Description

N-(2-hydroxyethyl)-N-methylformamide is a chemical compound that is commonly used as a solvent in various industrial processes, including pharmaceuticals, pesticides, and polymers manufacturing. It is a clear, colorless liquid with a faint odor and is highly soluble in water. This chemical is also known to have potential health hazards, as it can cause irritation to the skin, eyes, and respiratory system upon prolonged exposure. It is important to handle and use N-(2-hydroxyethyl)-N-methylformamide with proper safety measures and in a well-ventilated area to minimize the risk of adverse health effects.

InChI:InChI=1/C4H9NO2/c1-5(4-7)2-3-6/h4,6H,2-3H2,1H3

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 109-94-4 formic acid ethyl ester 
• 176964-68-4 3,4,9-triaza-2,2,9-trimethyl-1,6-dioxaspiro[4.4]non-3-ene 
• 124-38-9 carbon dioxide 

Downstream Products

• 106053-15-0 Phthalsaeure-N-formyl-N-methylaminoethylester 
• 340026-88-2 Diethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-(formyl-methyl-amino)-ethyl ester 
• 860303-70-4 N₄-benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-[2-(N-formyl-N-methylamino)ethoxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxycytidine 
• 1421922-27-1 N-{2-[(4-methoxybenzyl)oxy]ethyl}-N-methylformamide 

Relevant articles and documents

N-(2-Hydroxypropyl)formamide and N-(2-hydroxyethyl)-N-methylformamide as two new plasticizers for thermoplastic starch

N-(2-Hydroxypropyl)formamide (HPF) and N-(2-hydroxyethyl)-N-methylformamide (HMF) were used independently as new plasticizers for corn starch to prepare thermoplastic starch (TPS). The hydrogen bond interaction between HPF (or HMF) and starch was proven by Fourier-transform infrared spectroscopy. By scanning electron microscopy, starch granules were shown to be completely disrupted and homogeneous materials were obtained. The crystallinity of corn starch, HPF-plasticized TPS (PTPS) and HMF-plasticized TPS (MTPS) was characterized by X-ray diffraction. The crystallinity of TPS was affected by the structure of plasticizer. The water resistance of PTPS was better than that of MTPS. At medium relative humidity (RH), both tensile strength and elongation at break of PTPS were higher than those of MTPS. At high RH, the elongation at break of PTPS was higher than that of MTPS, while the tensile strength of PTPS was close to that of MTPS.

Combining Low-Pressure CO2 Capture and Hydrogenation to Form Methanol

This paper describes a novel approach to CO2 hydrogenation, in which CO2 capture with aminoethanols at low pressure is coupled with hydrogenation of the captured product, oxazolidinone, directly to MeOH. In particular, (2-methylamino)ethanol or valinol captures CO2 at 1-3 bar in the presence of catalytic Cs2CO3 to give the corresponding oxazolidinones in up to 65-70 and 90-95% yields, respectively. Efficient hydrogenation of oxazolidinones was achieved using PNN pincer Ru catalysts to give the corresponding aminoethanol (up to 95-100% yield) and MeOH (up to 78-92% yield). We also have shown that both CO2 capture and oxazolidinone hydrogenation can be performed in the same reaction mixture using a simple protocol that avoids intermediate isolation or purification steps. For example, CO2 can be captured by valinol at 1 bar with Cs2CO3 catalyst followed by 4-isopropyl-2-oxazolidinone hydrogenation in the presence of a bipy-based pincer Ru catalyst to produce MeOH in 50% yield after two steps.

CpG OLIGONUCLEOTIDE PRODRUGS, COMPOSITIONS THEREOF AND ASSOCIATED THERAPEUTIC METHODS

The present invention provides a CpG oligonucleotide prodrug that includes a thermolabile substituent on at least one nucleotide thereof. The present invention also provides compositions that include a carrier and a therapeutically effective amount of at least one CpG oligonucleotide prodrug. The present invention further provides therapeutic methods of using such thermolabile CpG oligonucleotide prodrugs and compositions thereof. The present invention further provides a method of inhibiting tetrad formation in a CpG oligonucleotide by functionalizing the CpG oligonucleotide with one or more thermolabile substituents.