34098-18-5

Basic information

• Product Name: 3-CHLORO-4,5-DIHYDROXYBENZALDEHYDE
• Synonyms: 3-Chloro-4,5-dihydroxybenzaldehyde;Benzaldehyde, 3-chloro-4,5-dihydroxy-
• CAS NO: 34098-18-5
• Molecular Formula: C₇H₅ClO₃
• Molecular Weight: 172.57
• Mol File: 34098-18-5.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 290.7 °C at 760 mmHg
• Flash Point: 129.6 °C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 0.00117mmHg at 25°C
• Refractive Index: 1.682
• CAS DataBase Reference: 3-CHLORO-4,5-DIHYDROXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4,5-DIHYDROXYBENZALDEHYDE(34098-18-5)
• EPA Substance Registry System: 3-CHLORO-4,5-DIHYDROXYBENZALDEHYDE(34098-18-5)

Safety Data

• Hazardous Substances Data: 34098-18-5(Hazardous Substances Data)

Usage

General Description

3-CHLORO-4,5-DIHYDROXYBENZALDEHYDE is an organic compound with the molecular formula C7H5ClO3. It is a chlorinated derivative of 4,5-dihydroxybenzaldehyde, and it is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. This chemical compound is also known for its antioxidant and antibacterial properties, making it useful in the development of skincare and personal care products. Additionally, 3-CHLORO-4,5-DIHYDROXYBENZALDEHYDE has been studied for its potential anti-inflammatory and anti-cancer properties, further expanding its potential applications in the medical and healthcare industries.

InChI:InChI=1/C7H5ClO3/c8-5-1-4(3-9)2-6(10)7(5)11/h1-3,10-11H

Upstream product

• 19463-48-0 5-chlorovanillin 
• 76681-74-8 C₂₃H₁₆O₈ 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 121-33-5 vanillin 
• 100-52-7 benzaldehyde 
• 621-59-0 isovanillin 
• 54246-06-9 3-chloro-5-hydroxy-4-methoxybenzaldehyde 

Downstream Products

• 84356-89-8 5'-chloro-sulfuretin 
• 84356-87-6 C₂₃H₁₅ClO₈ 
• 88525-51-3 7-chlorobenzo[d][1,3]dioxole-5-carbaldehyde 
• 33584-87-1 3-chloro-4,5-di(phenylmethoxy)benzaldehyde 
• 682744-11-2 3,4-bis(tert-butyldimethylsilyloxy)-5-chlorobenzaldehyde 
• 765950-74-1 formic acid 3,4-bis-benzyloxy-5-chloro-phenyl ester 
• 765950-75-2 3,4-dibenzyloxy-5-chlorophenol 
• 682744-39-4 3,4-bis(tert-butyldimethylsilyloxy)-5-chlorophenyl formate 
• 682744-14-5 3,4-bis(tert-butyldimethylsilyloxy)-5-chlorophenol 
• 682744-15-6 2-bromo-3-chloro-4,5-bis(tert-butyldimethylsilyloxy)phenol 
• 765950-76-3 1,2-dibenzyloxy-3-chloro-5-(tert-butyldimethylsilyloxy)benzene 
• 682744-12-3 3-chloro-1,2,5-tris(tert-butyldimethylsilyloxy)benzene 
• 682744-25-8 4-bromo-3-chloro-1,2-dibenzyloxy-5-(tert-butyldimethylsilyloxy)benzene 
• 682744-08-7 5-bromo-6-chloro-1,2,4-tris(tert-butyldimethylsilyloxy)benzene 

Relevant articles and documents

IMIDAXOPYROLONE COMPOUND AND APPLICATION THEREOF

Disclosed is a novel class of MDM2-p53 inhibitor compounds having an imidaxopyrolone structure, and specifically disclosed are compounds represented by formulas (I-1) and (I-2) and pharmaceutically acceptable salts thereof. (I-1), (I-2)

2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF

Compounds of formula (II) are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).

Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors

The development of inhibitors blocking STAT3 transcriptional activity is a promising therapeutic approach against cancer and inflammatory diseases. In this context, the selectivity of inhibitors against the STAT1 transcription factor is crucial as STAT3 and STAT1 play opposite roles in the apoptosis of tumor cells and polarization of the immune response. A structure-based virtual screening followed by a luciferase-containing promoter assay on STAT3 and STAT1 signaling were used to identify a selective STAT3 inhibitor. An important role of the aminotetrazole group in modulating STAT3 and STAT1 inhibitory activities has been established. Optimization of the hit compound leads to 23. This compound inhibits growth and survival of cells with STAT3 signaling pathway while displaying a minimal effect on STAT1 signaling. Moreover, it prevents lymphocyte T polarization into Th17 and Treg without affecting their differentiation into Th1 lymphocyte.