682744-11-2

Basic information

• Product Name: Benzaldehyde, 3-chloro-4,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
• CAS NO: 682744-11-2
• Molecular Formula: C19H33ClO3Si2
• Molecular Weight: 401.093
• Mol File: 682744-11-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 3-chloro-4,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 3-chloro-4,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(682744-11-2)
• EPA Substance Registry System: Benzaldehyde, 3-chloro-4,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(682744-11-2)

Safety Data

• Hazardous Substances Data: 682744-11-2(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 34098-18-5 5-chloro-3,4-dihydroxybenzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 19463-48-0 5-chlorovanillin 

Downstream Products

• 682744-08-7 5-bromo-6-chloro-1,2,4-tris(tert-butyldimethylsilyloxy)benzene 
• 682744-12-3 3-chloro-1,2,5-tris(tert-butyldimethylsilyloxy)benzene 
• 682744-15-6 2-bromo-3-chloro-4,5-bis(tert-butyldimethylsilyloxy)phenol 
• 682744-14-5 3,4-bis(tert-butyldimethylsilyloxy)-5-chlorophenol 
• 682744-39-4 3,4-bis(tert-butyldimethylsilyloxy)-5-chlorophenyl formate 

Relevant articles and documents

Redox potentials, laccase oxidation, and antilarval activities of substituted phenols

Laccases are copper-containing oxidases that are involved in sclerotization of the cuticle of mosquitoes and other insects. Oxidation of exogenous compounds by insect laccases may have the potential to produce reactive species toxic to insects. We investigated two classes of substituted phenolic compounds, halogenated di- and trihydroxybenzenes and substituted di-tert-butylphenols, on redox potential, oxidation by laccase and effects on mosquito larval growth. An inverse correlation between the oxidation potentials and laccase activity of halogenated hydroxybenzenes was found. Substituted di-tert-butylphenols however were found to impact mosquito larval growth and survival. In particular, 2,4-di-tert-butyl-6-(3-methyl-2-butenyl)phenol (15) caused greater than 98% mortality of Anopheles gambiae larvae in a concentration of 180 nM, whereas 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-methylpropanal oxime (13) and 6,8-di-tert-butyl-2,2-dimethyl-3,4-dihydro-2H-chromene (33) caused 93% and 92% mortalities in concentrations of 3.4 and 3.7 μM, respectively. Larvae treated with di-tert-butylphenolic compounds died just before pupation.

Compounds affecting cholesterol absorption

A class of novel compounds is described for use in affecting lymphatic absorption of cholesterol. Compounds of particular interest are defined by Formula I: or a pharmaceutically acceptable salt thereof.