342-23-4

Basic information

• Product Name: 2,2'-difluorobenzophenone
• Synonyms: 2,2'-difluorobenzophenone;Bis(2-fluorophenyl) ketone;bis(2-fluorophenyl)methanone
• CAS NO: 342-23-4
• Molecular Formula: C₁₃H₈F₂O
• Molecular Weight: 218.1988264
• EINECS: 206-439-6
• Mol File: 342-23-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 331.2°Cat760mmHg
• Flash Point: 127°C
• Appearance: /
• Density: 1.239g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,2'-difluorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-difluorobenzophenone(342-23-4)
• EPA Substance Registry System: 2,2'-difluorobenzophenone(342-23-4)

Safety Data

• Hazardous Substances Data: 342-23-4(Hazardous Substances Data)

Usage

General Description

2,2'-difluorobenzophenone, also known as benzophenone-1, is a benzophenone derivative with two fluorine atoms attached to the carbon atoms at the 2 position of the benzene rings. It is a yellow crystalline solid at room temperature and is insoluble in water. 2,2'-difluorobenzophenone is primarily used as a UV absorber in sunscreens and other cosmetic products to protect the skin and hair from damage caused by exposure to UV radiation. It functions by absorbing and dissipating UVB rays, thus preventing them from penetrating the skin and causing damage. It is also used as a photoinitiator in the manufacturing of polymers, coatings, adhesives, and inks. However, it has been found to have potential endocrine-disrupting properties, leading to concerns about its safety and environmental impact.

Upstream product

• 261925-13-7 bis(2-fluorophenyl)methanol 
• 126348-18-3 2,2'-difluorobenzilic acid 
• 1072-85-1 o-fluorobromobenzene 
• 393-52-2 2-Fluorobenzoyl chloride 
• 1993-03-9 o-fluorophenylboronic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 201230-82-2 carbon monoxide 
• 462-06-6 fluorobenzene 
• 119-61-9 benzophenone 
• 213128-18-8 benzyl (diphenylmethylene)carbamate 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 126348-19-4 diethyl di(2-fluorophenyl)methylenemalonate 
• 1026270-18-7 3,3-Bis-(2-fluoro-phenyl)-oxirane-2-carboxylic acid methyl ester 
• 1012079-84-3 2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3,3-bis-(2-fluoro-phenyl)-3-methoxy-propionic acid methyl ester 
• 126348-24-1 2-propane-1,3-diol 
• 126348-20-7 diethyl 2-malonate 
• 845821-92-3 2,2’-bis(diphenylphosphino)-benzophenone 
• 1307862-95-8 C₁₈H₁₆F₂O₂ 
• 1307863-08-6 ((2S,3S)-3-bromo-2-(2-fluorophenyl)-tetrahydro-2H-pyran-2-yl)-2-fluorophenylmethanone 
• 1307863-20-2 ((2R,3R)-3-bromo-2-(2-fluorophenyl)-tetrahydro-2H-pyran-2-yl)-2-fluorophenylmethanone 
• 1307863-29-1 ((2S,3S)-3-chloro-2-(2-fluorophenyl)-tetrahydro-2H-pyran-2-yl)-2-fluorophenylmethanone 
• 1307863-34-8 ((2R,3R)-3-chloro-2-(2-fluorophenyl)-tetrahydro-2H-pyran-2-yl)-2-fluorophenylmethanone 
• 1314028-10-8 2,2'-difluoro-5,5'-dinitrobenzophenone 

Relevant articles and documents

Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib

The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.

Tailoring Diindenochrysene through Intramolecular Multi-Assemblies by C?F Bond Activation on Aluminum Oxide

The unique nature of the alumina-mediated cyclodehydrofluorination gives the opportunity to execute the preprogrammed algorithm of the C?C couplings rationally built into a precursor. Such multi-assemblies facilitate the construction of the carbon-skeleton, superseding the conventional step-by-step by the one-pot intramolecular assembly. In this work, the feasibility of the alumina-mediated C?F bond activation approach for multi-assembly is demonstrated on the example of a fundamental bowl-shaped polycyclic aromatic hydrocarbon (diindenochrysene) through the formation of all “missing” C?C bonds at the last step. Beside valuable insights into the reaction mechanism and the design of the precursors, a facile pathway enabling the two-step synthesis of diindenochrysene was elaborated, in which five C?C bonds form in a single synthetic step. It is shown that the relative positions of fluorine atoms play a crucial role in the outcome of the assembly and that governing the substituent positions enables the design of effective precursor molecules “programmed” for the consecutive C?C bond formations. In general, these findings push the state of the field towards the facile synthesis of sophisticated bowl-shaped carbon-based nanostructures through multi-assembly of fluoroarenes.

Ligand-Free Palladium-Catalyzed Oxidative Carbonylative Homocoupling of Arylboron Reagents at Ambient Pressure

Arylboronic acids or potassium aryltrifluoroborates were readily oxidatively carbonylated to their corresponding diaryl ketones in high yields with high selectivities by ligand-free palladium-catalyzed homocoupling at atmospheric pressure. This novel method employs molecular oxygen or iodine as the oxidant and offers an attractive alternative to transition-metal-based oxidant systems.