34237-21-3

Basic information

• Product Name: (S)-2-Amino-4-methylpentanoic acid sodium salt
• Synonyms: (S)-2-Amino-4-methylpentanoic acid sodium salt;Leucine sodium salt
• CAS NO: 34237-21-3
• Molecular Formula: C₆H₁₂NO₂*Na
• Molecular Weight: 0
• Mol File: 34237-21-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-Amino-4-methylpentanoic acid sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Amino-4-methylpentanoic acid sodium salt(34237-21-3)
• EPA Substance Registry System: (S)-2-Amino-4-methylpentanoic acid sodium salt(34237-21-3)

Safety Data

• Hazardous Substances Data: 34237-21-3(Hazardous Substances Data)

Usage

Description

(S)-2-Amino-4-methylpentanoic acid sodium salt, a derivative of the amino acid leucine, is a white crystalline powder that is soluble in water. It is widely recognized for its role in protein synthesis and is frequently utilized as a biochemical reagent in laboratory settings.

Uses

Used in Biochemical Research:
(S)-2-Amino-4-methylpentanoic acid sodium salt is used as a biochemical reagent for its role in protein synthesis and as a building block for the production of peptides and proteins in biotechnology and pharmaceutical research.
Used in Pharmaceutical Research:
(S)-2-Amino-4-methylpentanoic acid sodium salt is used as a building block for the development of therapeutic drugs, particularly in the treatment of muscle disorders and metabolic diseases.
Used in Biotechnology:
(S)-2-Amino-4-methylpentanoic acid sodium salt is used as a key component in the production of peptides and proteins, contributing to the advancement of biotechnological applications and innovations.

Upstream product

• 32256-50-1 N-(1-methyl-2-ethoxycarbonylvinyl)-L-leucine sodium salt 
• 61-90-5 L-leucine 

Downstream Products

• 14379-43-2 N-octadecanoyl leucine 
• 57744-46-4 Ac-ΔPhe-(S)-Leu-OH 
• 116628-53-6 Diphenylborinsaeure-L-leucin-anhydrid 
• 175029-33-1 (S)-2-(2-hydroxybenzylamino)-4-methylpentanoic acid 
• 38155-16-7 Ac-(S)-Phe-(S)-Leu-OH 
• 38155-17-8 Ac-(R)-Phe-(S)-Leu-OH 
• 181590-96-5 Ac-ΔPhe-(S)-Leu-OMe 
• 38155-12-3 Ac-(R)-Phe-(S)-Leu-OMe 
• 38155-11-2 Ac-(S)-Phe-(S)-Leu-OMe 
• 3190-70-3 L-leucine N-carboxyanhydride 

Relevant articles and documents

Synthesis, characterization, DNA and HSA binding studies of isomeric Pd (II) antitumor complexes using spectrophotometry techniques

Two new Palladium(II) isomeric complexes, [Pd (Gly)(Leu)](I) and [Pd (Gly)(Ile)](II), where Gly is glycine, and Leu and Ile are isomeric amino acids (leucine and isoleucine), have been synthesized and characterized by elemental analysis, molar conductivity measurements, FT-IR, 1H NMR, and UV–Vis. The complexes have been tested for their In vitro cytotoxicity against cancer cell line K562 and their binding properties to calf thymus DNA (CT-DNA) and human serum albumin (HSA) have also been investigated by multispectroscopic techniques. Interactions of these complexes with CT-DNA were monitored using gel electrophoresis. The energy transfer from HSA to these complexes and the binding distance between HSA and the complexes (r) were calculated. The results obtained from these studies indicated that at very low concentrations, both complexes effectively interact with CT-DNA and HSA. Fluorescence studies revealed that the complexes strongly quench DNA bound ethidium bromide as well as the intrinsic fluorescence of HSA through the static quenching procedures. Binding constant (Kb), apparent biomolecular quenching constant (kq), and number of binding sites (n) for CT-DNA and HSA were calculated using Stern–Volmer equation. The calculated thermodynamic parameters indicated that the hydrogen binding and vander Waals forces might play a major role in the interaction of these complexes with HSA and DNA. Thus, we propose that the complexes exhibit the groove binding with CT-DNA and interact with the main binding pocket of HSA. The complexes follow the binding affinity order of I?>?II with DNA- and II?>?I with HSA-binding.

Hydration of amino acids from ultrasonic measurements

In this paper the results of compressibility of aqueous solutions of amino acids in water and in aqueous HCl and NaOH solutions at 25 °C are presented. The effect of the charged protonated amino groups and deprotonated carboxylic groups on the hydration number was tested. The idea of additivity of the hydration number with the constituents of the solute molecule was successfully applied and discussed.