38155-11-2

Basic information

• Product Name: L-Leucine, N-(N-acetyl-L-phenylalanyl)-, methyl ester
• CAS NO: 38155-11-2
• Molecular Formula: C18H26N2O4
• Molecular Weight: 334.415
• Mol File: 38155-11-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-(N-acetyl-L-phenylalanyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-(N-acetyl-L-phenylalanyl)-, methyl ester(38155-11-2)
• EPA Substance Registry System: L-Leucine, N-(N-acetyl-L-phenylalanyl)-, methyl ester(38155-11-2)

Safety Data

• Hazardous Substances Data: 38155-11-2(Hazardous Substances Data)

Upstream product

• 93509-88-7 Ac-ΔPhe-(R)-Leu-OMe 
• 181590-96-5 Ac-ΔPhe-(S)-Leu-OMe 
• 506-96-7 Acetyl bromide 
• 3850-45-1 Cbz-L-Phe-L-Leu-OMe 
• 38155-45-2 methyl L-phenylalanyl-L-leucinate hydrochloride 
• 57744-46-4 Ac-ΔPhe-(S)-Leu-OH 
• 34237-21-3 (L)-leucine sodium salt 
• 38879-46-8 (Z)-4-benzylidene-2-methyl-5(4H)-oxazolone 

Relevant articles and documents

Lewis acid-catalyzed cleavage of carbamate and carbonate resins

A procedure for the preparation of amides and esters on a Merrifield resin-bound benzyloxycarbonyl equivalent has been developed. Polymer-supported carbamates react cleanly with zinc bromide and the appropriate acyl halide in the presence of triethylamine to provide their corresponding amides in high yields and purities. Cleavage of resin-bound carbonates was carried out using the similar reagent systems in the absence of triethylamine to give acetates or benzoates. (C) 2000 Elsevier Science Ltd.

ASYMMETRIC HOMOGENOUS REDUCTION OF DEHYDROPEPTIDES

Monodehydropeptides with the dehydroaminoacid fragment in C-terminal or N-terminal position were synthetized as well as a family with the general formula Ac-ΔPhe-(Gly)n-Leu-OR (n = 0-2, R = H or Me).Asymmetric reduction of these compounds catalyzed by chiral rhodium complexes was investigated.The results were discussed in terms of double asymmetric induction.A method was developped to avoid the use of both enantiomers of the substrate or of the catalyst, it consists in the total reduction of a racemic dehydropeptide.The products distribution gives access to the two desired facial selectivities.