38155-45-2

Basic information

• Product Name: L-Leucine, L-phenylalanyl-, methyl ester, monohydrochloride
• CAS NO: 38155-45-2
• Molecular Formula: C16H24N2O3.ClH
• Molecular Weight: 328.839
• Mol File: 38155-45-2.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: L-Leucine, L-phenylalanyl-, methyl ester, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, L-phenylalanyl-, methyl ester, monohydrochloride(38155-45-2)
• EPA Substance Registry System: L-Leucine, L-phenylalanyl-, methyl ester, monohydrochloride(38155-45-2)

Safety Data

• Hazardous Substances Data: 38155-45-2(Hazardous Substances Data)

Upstream product

• 4192-12-5 Boc-Phe-OH*DCHA 
• 6322-53-8 leucine methyl ester hydrochloride 
• 64152-76-7 Boc-Phe-Leu-OMe 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 63-91-2 L-phenylalanine 
• 61-90-5 L-leucine 
• 72015-61-3 (Z)-2-benzyloxycarbonylaminocinnamic acid 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 84759-67-1 CBZ-ΔPhe-L-Leu-OMe 
• 72015-61-3 2-benzyloxycarboxamidocinnamic acid 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 1161-13-3 N-Cbz-L-Phe 
• 2666-93-5 (S)-Leu-OMe 
• 188783-11-1 N-[N-(2-benzoyl-2-ethoxycarbonylvinyl-1)-L-3-phenylalanyl]-L-leucine methyl ester 

Downstream Products

• 111934-10-2 (S)-2-[(S)-2-(2-Aza-bicyclo[2.2.1]hept-5-en-2-yl)-3-phenyl-propionylamino]-4-methyl-pentanoic acid methyl ester 
• 64152-77-8 N-(tert-butyloxycarbonyl)glycyl-L-phenylalanyl-L-leucine methyl ester 
• 38155-11-2 Ac-(S)-Phe-(S)-Leu-OMe 
• 80727-50-0 Boc-Gly-Phe-Leu-N₂H₃ 
• 77591-04-9 Boc-Gly-Phe-Leu-Tyr-Gly-OMe 
• 80727-53-3 Boc-Gly-Phe-Leu-Tyr-Gly-N₂H₃ 
• 75975-40-5 cyclo-Leu⁵-Enkephalin 
• 1228804-18-9 [3-(Fmoc-glycylamino)-2-methylenepropanoyl]-L-phenylalaninyl-L-leucine methyl ester 
• 1365292-44-9 L-isoseryl-L-phenylalanyl-L-leucine methyl ester hydrochloride 
• 1371571-05-9 BrCH₂CO-Phe-Leu-OMe 
• 1379456-55-9 Br^(1-)*C₂₂H₃₁N₄O₄⁽¹⁺⁾ 
• 1338587-04-4 (S)-tert-butyl 3-(((S)-1-(((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 88816-04-0 (S)-2-{(S)-2-[2-(2-Amino-thioacetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester 
• 113266-48-1 (S)-2-[(S)-2-(2-{2-[(S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionylamino]-thioacetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid methyl ester 

Relevant articles and documents

Peptide-Catalyzed Fragment Couplings that Form Axially Chiral Non-C2-Symmetric Biaryls

We have demonstrated that small, modular, tetrameric peptides featuring the Lewis-basic residue β-dimethylaminoalanine (Dmaa) are capable of atroposelectively coupling naphthols and ester-bearing quinones to yield non-C2-symmetric BINOL-type scaffolds with good yields and enantioselectivity. The study culminates in the asymmetric synthesis of backbone-substituted scaffolds similar to 3,3′-disubstituted BINOLs, such as (R)-TRIP, with good (94:6 e.r.) to excellent (>99.9:0.1 e.r.) enantioselectivity after recrystallization, and a diastereoselective net arylation of the minimally modified nonsteroidal anti-inflammatory drug (NSAID) naproxen.

Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors

A series of novel L-isoserine derivatives were synthesised and evaluated for their ability to inhibit aminopeptidase N (APN)/CD13. In our preliminary biological results, some of these compounds possessed a potent inhibitory activity against the APN. Within this series, compound 14b not only showed similar enzyme inhibition (IC50 of 12.2μM) compared with the positive control bestatin (half maximal inhibitory concentration (IC 50) of 7.3μM), but also had a potent antiproliferative activity against human cancer cell lines cells.

Efficient synthesis of 2,5-diketopiperazines using microwave assisted heating

In this study a general, efficient and environmentally benign solution phase synthesis of 2,5-diketopiperazines (DKPs) using microwave assisted heating in water is described. A series of 11 structurally different DKPs have been synthesized from dipeptide methyl esters. A range of common laboratory solvents have been tested as well as different reaction times and temperatures. Both classic thermal and microwave assisted heating have been investigated. Microwave assisted heating for 10 min using water as solvent proved, by far, to be the most efficient method of cyclization giving moderate to excellent yields (63-97%) of DKPs. In contrast to other published procedures, this method seems independent of the amino acid sequence.