343-26-0 Usage
Description
6-Fluoro-8-nitroquinoline is an organic compound characterized by the presence of a fluorine atom at the 6th position and a nitro group at the 8th position in its quinoline ring structure. It is a synthetic intermediate with potential applications in various fields due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
6-Fluoro-8-nitroquinoline is used as a synthetic intermediate for the production of 6-Fluoro-8-Quinolinesulfonyl Chloride (F596550). 6-fluoro-8-nitroquinoline may have potential applications as a clastogenic agent, which can induce chromosomal breakage and rearrangements, and as an inhibitor of cytochrome P450 (CYP) enzymes due to the presence of the quinoline moiety in its substructure. These properties make it a valuable compound for research and development in the pharmaceutical industry, particularly in the areas of drug discovery and design.
Additionally, 6-Fluoro-8-nitroquinoline may also be used as a building block for the synthesis of other quinoline-based compounds with potential applications in various industries, such as agrochemicals, dyes, and materials science. However, further research and development are required to fully explore and understand the potential applications of this compound in these areas.
Check Digit Verification of cas no
The CAS Registry Mumber 343-26-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 3 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 343-26:
(5*3)+(4*4)+(3*3)+(2*2)+(1*6)=50
50 % 10 = 0
So 343-26-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H5FN2O2/c10-7-4-6-2-1-3-11-9(6)8(5-7)12(13)14/h1-5H
343-26-0Relevant articles and documents
Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway
Sen, Chiranjit,Sahoo, Tapan,Singh, Harshvardhan,Suresh, Eringathodi,Ghosh, Subhash Chandra
, p. 9869 - 9896 (2019/08/20)
An efficient photocatalytic method was developed for the remote C5-H bond carboxylation of 8-aminoquinoline amide and sulfonamide derivatives. This methodology uses in situ generated ?CBr3 radical as a carboxylation agent with alcohol and is further extended to a variety of arenes and heteroarenes to synthesize the desired carboxylated product in moderate-to-good yields. The reaction proceeding through a single electron transfer pathway was established by a control experiment, and a butylated hydroxytoluene-trapped aryl radical cation intermediate in high-resolution mass spectrometry was identified.
THERAPEUTIC COMPOUNDS AND COMPOSITIONS
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Paragraph 0743; 0744, (2014/09/30)
Compounds of general formula I: and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.
Novel Sulfonaminoquinoline Hepcidin Antagonists
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Page/Page column 128, (2012/09/05)
The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.