343-54-4

Basic information

• Product Name: 6-FLUOROQUINOLIN-8-AMINE
• Synonyms: 6-FLUOROQUINOLIN-8-AMINE
• CAS NO: 343-54-4
• Molecular Formula: C9H7FN2
• Molecular Weight: 162.16
• Product Categories: organic building block
• Mol File: 343-54-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 323.786 °C at 760 mmHg
• Flash Point: 149.621 °C
• Appearance: /
• Density: 1.316 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 6-FLUOROQUINOLIN-8-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUOROQUINOLIN-8-AMINE(343-54-4)
• EPA Substance Registry System: 6-FLUOROQUINOLIN-8-AMINE(343-54-4)

Safety Data

• Hazardous Substances Data: 343-54-4(Hazardous Substances Data)

Usage

Description

6-FLUOROQUINOLIN-8-AMINE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by the presence of a fluorine atom at the 6th position and an amine group at the 8th position of the quinoline ring, which contributes to its unique chemical properties and potential applications in the pharmaceutical industry.

Uses

Used in Pharmaceutical Synthesis:
6-FLUOROQUINOLIN-8-AMINE is used as an intermediate in the synthesis of 6-Fluoro-8-Quinolinesulfonyl Chloride (F596550), a compound that may exhibit clastogenic properties and act as an inhibitor of CYP enzymes. The presence of the quinoline moiety in its substructure is responsible for these potential biological activities.
In the pharmaceutical industry, 6-FLUOROQUINOLIN-8-AMINE plays a vital role in the development of new drugs targeting various diseases and conditions. Its unique chemical structure allows for the creation of novel compounds with potential therapeutic applications, making it a valuable asset in the field of medicinal chemistry.

Upstream product

• 343-26-0 6-fluoro-8-nitroquinoline 
• 364-78-3 2-nitro-4-fluoroaniline 
• 396-30-5 6-fluoroquinoline 
• 394-70-7 4-Fluoroquinoline 
• 351-83-7 4'-fluoroacetanilide 
• 448-39-5 N-(4-fluoro-2-nitrophenyl)acetamide 

Downstream Products

• 442-65-9 4-fluoro-benzenesulfonic acid-(6-fluoro-[8]quinolylamide) 
• 575-21-3 N-(6-fluoro-[8]quinolyl)-anthranilic acid 

Relevant articles and documents

Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway

An efficient photocatalytic method was developed for the remote C5-H bond carboxylation of 8-aminoquinoline amide and sulfonamide derivatives. This methodology uses in situ generated ?CBr3 radical as a carboxylation agent with alcohol and is further extended to a variety of arenes and heteroarenes to synthesize the desired carboxylated product in moderate-to-good yields. The reaction proceeding through a single electron transfer pathway was established by a control experiment, and a butylated hydroxytoluene-trapped aryl radical cation intermediate in high-resolution mass spectrometry was identified.

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Compounds of general formula (I) and compositions comprising compounds of general formula (I) that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.