343-67-9

Basic information

• Product Name: ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
• Synonyms: ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE;ethyl 4-hydroxy-2-(trifluoromethyl)-5-pyrimidinecarboxylate;Ethyl 4-hydroxy-2-(trifluoromethyl)pyrimidine-5-carboxylate ,97%;ethyl 6-oxo-2-(trifluoroMethyl)-1,6-dihydropyriMidine-5-carboxylate;Ethyl 2-trifluoromethyl-4-oxopyrimidine-5-carboxylate;5-(Ethoxycarbonyl)-4-hydroxy-2-(trifluoromethyl)pyrimidine, 5-(Ethoxycarbonyl)-4-hydroxy-2-(trifluoromethyl)-1,3-diazine
• CAS NO: 343-67-9
• Molecular Formula: C₈H₇F₃N₂O₃
• Molecular Weight: 236.1479896
• Product Categories: pyrimidine;Fluorine series
• Mol File: 343-67-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 315-316°
• Boiling Point: 220.8 °C at 760 mmHg
• Flash Point: 87.4 °C
• Appearance: /
• Density: 1.50
• Vapor Pressure: 0.0747mmHg at 25°C
• Refractive Index: 1.499
• Storage Temp.: 2-8°C
• PKA: 4.75±0.50(Predicted)
• CAS DataBase Reference: ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE(343-67-9)
• EPA Substance Registry System: ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE(343-67-9)

Safety Data

• Hazard Codes: Xi
• Statements: 48-20/21/22
• Safety Statements: 3/7/9-37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 343-67-9(Hazardous Substances Data)

Usage

Description

ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE is a white solid compound that serves as a valuable reagent in the study of NF-κB and AP-1 gene inhibitors. Its unique chemical structure allows it to be utilized in various research and development applications, particularly in the field of molecular biology and pharmaceuticals.

Uses

Used in Pharmaceutical Research:
ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE is used as a research reagent for studying the inhibition of NF-κB and AP-1 genes. This is important because these genes play a significant role in regulating cellular responses to various stimuli, including stress, cytokines, and bacterial or viral antigens. By inhibiting these genes, researchers can gain insights into the development of potential therapeutic strategies for various diseases and conditions.
Used in Drug Development:
In the pharmaceutical industry, ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE is used as a key intermediate in the synthesis of novel compounds with potential therapeutic applications. Its unique chemical properties make it a valuable building block for the development of new drugs targeting various diseases, including inflammatory disorders, autoimmune conditions, and cancer.
Used in Molecular Biology:
ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE is also used in molecular biology as a tool to study gene regulation and signal transduction pathways. By understanding how this compound interacts with NF-κB and AP-1 genes, researchers can develop a better understanding of the underlying mechanisms involved in these processes, which can ultimately lead to the development of targeted therapies for various diseases.

InChI:InChI=1/C8H7F3N2O3/c1-2-16-6(15)4-3-12-7(8(9,10)11)13-5(4)14/h3H,2H2,1H3,(H,12,13,14)

Upstream product

• 354-37-0 trifluoroacetamidine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 37555-99-0 diethyl ethoxymalonate 
• 7732-18-5 water 

Downstream Products

• 720-01-4 ethyl 2-trifluoromethyl-4-chloropyrimidine-5-carboxylate 
• 304693-64-9 ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate 
• 2924-82-5 4-Hydrazino-2-trifluormethyl-pyrimidin-carbonsaeure-(5)-ethylester 

Relevant articles and documents

BENZAMIDE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING INFLAMMATORY DISEASE CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a benzamide derivative compound, a method for preparing the same, and a pharmaceutical composition for treating or preventing an inflammatory disease containing the same as an active ingredient. The benzamide derivative compound according to the present invention inhibits the expression of PDE4 and regulates the expression of an inflammatory disease-related substance such as IL-4 (interleukin-4), IL-5 (interleukin-4), IFN-γ (interferon-γ), IL-17 (interluekin-17), IgE (immunoglobulin E), and TNF-α (tumor necrosis factor-α), and thus may be utilized as a pharmaceutical composition for treating or preventing an inflammatory disease.

Pyrimidinone compounds

Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.

Novel inhibitors of AP-1 and NF-κB mediated gene expression: Structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carb oxylate

In an effort to identify novel inhibitors of AP-1 and NF-κB mediated transcriptional activation, several analogues of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carb oxylate (1) were synthesized and tested in two in vitro assays. The 2-(2'-thienyl) substituted compound (11) was identified as the most potent in this series. (C) 2000 Elsevier Science Ltd. All rights reserved.