345-28-8

Basic information

• Product Name: 2-HYDROXY-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER
• Synonyms: RARECHEM AL BF 1424;2-HYDROXY-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER;2-HYDROXY-4-TRIFLUOROMETHYL METHYLBENZOATE;2-HYDROXY-4-TRIFLUROMETHYL METHYLBENZOATE
• CAS NO: 345-28-8
• Molecular Formula: C₉H₇F₃O₃
• Molecular Weight: 220.15
• Product Categories: pharmacetical
• Mol File: 345-28-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 245°Cat760mmHg
• Flash Point: 102°C
• Appearance: /
• Density: 1.382g/cm³
• Vapor Pressure: 0.0188mmHg at 25°C
• Refractive Index: 1.475
• CAS DataBase Reference: 2-HYDROXY-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER(345-28-8)
• EPA Substance Registry System: 2-HYDROXY-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER(345-28-8)

Safety Data

• Hazardous Substances Data: 345-28-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H7F3O3/c1-15-8(14)6-3-2-5(4-7(6)13)9(10,11)12/h2-4,13H,1H3

Upstream product

• 67-56-1 methanol 
• 328-90-5 4-trifluoromethylsalicylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 402-15-3 2-hydroxy-4-trifluoromethylbenzamide 
• 321-20-0 2-hydroxy-4-trifluoromethyl-benzoic acid hydrazide 
• 159691-51-7 2-Hydroxy-N-(2-hydroxy-ethyl)-4-trifluoromethyl-benzamide 
• 920334-16-3 methyl 2-(3-(methoxycarbonyl)propanoxy)-4-trifluoromethyl benzoate 
• 872191-23-6 2-ethoxycarbonylmethoxy-4-trifluoromethyl-benzoic acid methyl ester 
• 394-37-6 2,N-dihydroxy-4-trifluoromethyl-benzamide 
• 1236303-06-2 2-difluoromethoxy-4-trifluoromethyl-benzoic acid methyl ester 
• 1175134-69-6 2-isopropoxy-4-trifluoromethyl-benzoic acid 
• 1572936-93-6 2-trifluoromethylsulfonyloxy-4-trifluoromethylbenzoic acid methylester 
• 1578179-21-1 N-(4-chlorophenyl)-4-trifluoromethylanthranilic acid 
• 1578179-23-3 N-(4-bromophenyl)-4-trifluoromethylanthranilic acid 
• 1578179-27-7 N-(4-nitrophenyl)-4-trifluoromethylanthranilic acid 
• 1578179-29-9 N-(4-trifluoromethylphenyl)-4-trifluoromethylanthranilic acid 
• 1578179-31-3 C₁₅H₁₁ClF₃NO₂ 

Relevant articles and documents

Catalytic Carbochlorocarbonylation of Unsaturated Hydrocarbons via C?COCl Bond Cleavage**

Here we report a palladium-catalysed difunctionalisation of unsaturated C?C bonds with acid chlorides. Formally, the C?COCl bond of an acid chloride is cleaved and added, with complete atom economy, across either strained alkenes or a tethered alkyne to generate new acid chlorides. The transformation does not require exogenous carbon monoxide, operates under mild conditions, shows a good functional group tolerance, and gives the isolated products with excellent stereoselectivity. The intermolecular reaction tolerates both aryl- and alkenyl-substituted acid chlorides and is successful when carboxylic acids are transformed to the acid chloride in situ. The reaction also shows an example of temperature-dependent stereodivergence which, together with plausible mechanistic pathways, is investigated by DFT calculations. Moreover, we show that benzofurans can be formed in an intramolecular variant of the reaction. Finally, derivatisation of the products from the intermolecular reaction provides a highly stereoselective approach for the synthesis of tetrasubstituted cyclopentanes.

Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase

This disclosure relates to compounds for the inhibition of histone deacetylase and treatment of a cognitive disorder or deficit. More particularly, the disclosure provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.

NOVEL COMPOUNDS AS CHLORIDE CHANNEL BLOCKING AGENT

Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.