328-90-5 Usage
Description
4-Trifluoromethylsalicylic acid, also known as the active metabolite of Triflusal, is a white to off-white solid with significant biological activities. It is derived from the metabolism of Triflusal, a drug used for various therapeutic purposes. 4-Trifluoromethylsalicylic acid possesses unique chemical properties that make it a valuable compound in the pharmaceutical and medical fields.
Uses
Used in Pharmaceutical Industry:
4-Trifluoromethylsalicylic acid is used as an active metabolite for Triflusal, a drug with various therapeutic applications. It is particularly effective in inhibiting cardiac hypertrophy, a condition characterized by the enlargement of the heart muscle, both in vitro and in vivo. This is achieved by blocking the NF-κB signaling pathway, which plays a crucial role in the development of cardiac hypertrophy.
Used in Cardiology:
In the field of cardiology, 4-Trifluoromethylsalicylic acid is used as a therapeutic agent for the treatment of cardiac hypertrophy. By inhibiting the NF-κB signaling pathway, it helps prevent the enlargement of the heart muscle, reducing the risk of heart failure and other cardiovascular complications. This makes it a promising candidate for the development of novel treatments for heart-related conditions.
Used in Research and Development:
4-Trifluoromethylsalicylic acid is also used as a valuable compound in research and development, particularly in the study of the NF-κB signaling pathway and its role in various diseases, including cardiac hypertrophy. Its unique chemical properties and biological activities make it an important tool for understanding the underlying mechanisms of these conditions and for the development of new therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 328-90-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,2 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 328-90:
(5*3)+(4*2)+(3*8)+(2*9)+(1*0)=65
65 % 10 = 5
So 328-90-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H5F3O3/c9-8(10,11)4-1-2-5(7(13)14)6(12)3-4/h1-3,12H,(H,13,14)
328-90-5Relevant articles and documents
Palladium-catalyzed ortho-C-H hydroxylation of benzoic acids
Luo, Feihua,He, Shuhua,Gou, Quan,Chen, Jinyang,Zhang, mingzhong
, (2021/10/06)
A simple Pd(OAc)2 catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant has been explored. This protocol features relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates is an effective complement to the previous ortho-hydroxylation reaction.
PD(II)-CATALYZED HYDROXYLATION OF ARENES WITH O2 OR AIR
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Page/Page column 14; 19-20, (2011/04/24)
Pd (II) -catalyzed ortho-hydroxylat ion of variously substituted aromatic carboxylic acids under O2 or air is achieved under non-acidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.
Pd(II)-catalyzed hydroxylation of arenes with 1 atm of O2 or air
Zhang, Yang-Hui,Yu, Jin-Quan
supporting information; experimental part, p. 14654 - 14655 (2010/01/06)
(Chemical Equation Presented) Pd(II)-catalyzed ortho-hydroxylation of variously substituted benzoic acids under 1 atm of O2 or air is achieved under nonacidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.
