334018-79-0

Basic information

• Product Name: 1-MethoxyMethoxy-3-trifluoroMethyl-benzene
• Synonyms: 1-MethoxyMethoxy-3-trifluoroMethyl-benzene
• CAS NO: 334018-79-0
• Molecular Formula: C₉H₉F₃O₂
• Molecular Weight: 206.1617696
• Mol File: 334018-79-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 210.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.214±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-MethoxyMethoxy-3-trifluoroMethyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-MethoxyMethoxy-3-trifluoroMethyl-benzene(334018-79-0)
• EPA Substance Registry System: 1-MethoxyMethoxy-3-trifluoroMethyl-benzene(334018-79-0)

Safety Data

• Hazardous Substances Data: 334018-79-0(Hazardous Substances Data)

Usage

Uses

1-(Methoxymethoxy)-3-(trifluoromethyl)benzene

Upstream product

• 98-17-9 3-Trifluoromethylphenol 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 368422-28-0 2-methoxymethoxy-6-(trifluoromethyl)benzoic acid 
• 368422-29-1 2-methoxymethoxy-4-(trifluoromethyl)benzene 
• 328-90-5 4-trifluoromethylsalicylic acid 
• 144433-66-9 2-hydroxy-6-(trifluoromethyl)benzoic acid 
• 102771-00-6 2-iodo-5-(trifluoromethyl)phenol 
• 380860-69-5 3-(2-iodo-5-trifluoromethyl-phenoxy)-3,6-dihydro-2H-pyridine-1-carboxylic acid ethyl ester 
• 380611-44-9 2-propylthio-3-methoxymethoxy-trifluoromethylbenzene 
• 1403382-14-8 ethyl 2-[2-(methoxymethoxy)-6-(trifluoromethyl)phenyl]-2-oxoacetate 
• 334015-45-1 2-(methoxymethoxy)-4-(trifluoromethyl)benzaldehyde 

Relevant articles and documents

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

Fluorophenols and (trifluoromethyl)phenols as substrates of site-selective metalation reactions: To protect or not to protect

O-Methoxymethyl (MOM) protected fluorophenols can be cleanly metalated and subsequently be submitted to site-selective electrophilic substitution. The 2- and 4-isomers exhibit ambivalent reactivity: deprotonation occurs at the position adjacent to the oxygen when butyllithium is employed whereas the position adjacent to the fluorine is attacked by the superbasic mixture of butyllithium and potassium tert-butoxide (LIC-KOR). The MOM-protected (trifluoromethyl)-phenols react exclusively at oxygen-neighboring positions. The meta isomer provides another example of optional site selectivity, undergoing hydrogen/metal exchange at the 2-position with the LIC-KOR reagent and at the 6-position with sec-butyllithium. Unprotected (trifluoromethyl)phenols can also be ortho-metalated after O-deprotonation, although the products are formed in only moderate yields.