345626-52-0

Basic information

• Product Name: 2-[(3-Chloro-4-cyano-phenylamino)-methylene]-malonic acid diethyl ester
• CAS NO: 345626-52-0
• Molecular Weight: 322.748
• Mol File: 345626-52-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[(3-Chloro-4-cyano-phenylamino)-methylene]-malonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(3-Chloro-4-cyano-phenylamino)-methylene]-malonic acid diethyl ester(345626-52-0)
• EPA Substance Registry System: 2-[(3-Chloro-4-cyano-phenylamino)-methylene]-malonic acid diethyl ester(345626-52-0)

Safety Data

• Hazardous Substances Data: 345626-52-0(Hazardous Substances Data)

Upstream product

• 20925-27-3 4-amino-2-chlorobenzonitrile 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Relevant articles and documents

Structure-Activity Relationships of Antibacterial 6,7- and 7,8-Disubstituted 1-Alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids

Previous quantitative and qualitative structure-activity studies in antibacterial monosubstituted 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids prompted us to synthesize the 6,7,8-polysubstituted compounds.In this paper, the preparation and antibacterial activity of the 6,7- and 7,8-disubstituted compounds and their derivatives are described.Among these compounds, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (34) possessed many significant activities and was more active than oxolinic acid (84) against Gram-positive andGram-negative bacteria.Structure activity relationships are discussed.