20925-27-3 Usage
Description
4-Amino-2-chlorobenzonitrile is an organic compound characterized by its white to light yellow crystal powder appearance. It is a derivative of benzonitrile, featuring an amino group at the 4-position and a chlorine atom at the 2-position. 4-Amino-2-chlorobenzonitrile is known for its versatile chemical properties, making it a valuable component in various industrial applications.
Uses
Used in Chemical Synthesis:
4-Amino-2-chlorobenzonitrile is used as an organic reagent for the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows it to serve as a key intermediate in the development of new molecules with specific biological activities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Amino-2-chlorobenzonitrile is used as a building block for the creation of novel drug candidates. Its chemical properties enable the formation of diverse molecular structures, which can be tailored to target specific biological pathways or receptors, potentially leading to the development of new therapeutic agents.
Used in Agrochemical Industry:
4-Amino-2-chlorobenzonitrile is also utilized in the agrochemical industry for the synthesis of pesticides and other crop protection agents. Its reactivity and structural diversity make it a valuable component in the design of new molecules with improved efficacy and selectivity against target pests.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 4-Amino-2-chlorobenzonitrile is employed as a starting material for the production of various organic dyes and pigments. Its chemical properties contribute to the development of colorants with enhanced stability, brightness, and fastness properties, which are essential for various applications, including textiles, plastics, and printing inks.
Used in Research and Development:
4-Amino-2-chlorobenzonitrile is also used in research and development laboratories for the exploration of new chemical reactions and the synthesis of novel compounds. Its unique structure and reactivity make it an attractive candidate for studying various aspects of organic chemistry, such as reaction mechanisms, stereochemistry, and the development of new synthetic methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 20925-27-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,9,2 and 5 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 20925-27:
(7*2)+(6*0)+(5*9)+(4*2)+(3*5)+(2*2)+(1*7)=93
93 % 10 = 3
So 20925-27-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H5ClN2/c8-7-3-6(10)2-1-5(7)4-9/h1-3H,10H2
20925-27-3Relevant articles and documents
Highly selective hydrogenation of halogenated nitroarenes over Ru/CN nanocomposites by: In situ pyrolysis
Yue, Shengnan,Wang, Xueguang,Li, Shaoting,Sheng, Yao,Zou, Xiujing,Lu, Xionggang,Zhang, Chunlei
, p. 11861 - 11869 (2020/07/28)
A highly chemoselective and recyclable ruthenium catalyst for the hydrogenation of halogenated nitroarenes has been prepared via the simple in situ calcination of a mixture of melamine, glucose and ruthenium trichloride. Superfine Ru particles (2.3 ± 0.3 nm) were obtained and highly dispersed in the nitrogen-doped carbon matrix. The Ru/CN catalyst smoothly transforms a variety of halogenated nitroarenes to the corresponding haloanilines with high intrinsic activity (e.g. TOF = 1333 h-1 for p-chloronitrobenzene) and selectivity of more than 99.6percent. Furthermore, through an analysis of the products in the reaction process, it was concluded that there are two parallel reaction pathways (a direct pathway and an indirect pathway) for the hydrogenation of aromatic nitro compounds over the Ru/CN catalyst, and the direct pathway was proved to be dominant in catalyzing the intermediates. This journal is
Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators
Hamann, Lawrence G.,Manfredi, Mark C.,Sun, Chongqing,Krystek Jr., Stanley R.,Huang, Yanting,Bi, Yingzhi,Augeri, David J.,Wang, Tammy,Zou, Yan,Betebenner, David. A.,Fura, Aberra,Seethala, Ramakrishna,Golla, Rajasree,Kuhns, Joyce E.,Lupisella, John A.,Darienzo, Celia J.,Custer, Laura L.,Price, Jennifer L.,Johnson, James M.,Biller, Scott A.,Zahler, Robert,Ostrowski, Jacek
, p. 1860 - 1864 (2008/02/04)
Pharmacokinetic studies in cynomolgus monkeys with a novel prototype selective androgen receptor modulator revealed trace amounts of an aniline fragment released through hydrolytic metabolism. This aniline fragment was determined to be mutagenic in an Ames assay. Subsequent concurrent optimization for target activity and avoidance of mutagenicity led to the identification of a pharmacologically superior clinical candidate without mutagenic potential.
Microwave thermolysis VII: Selective diversity in the reduction using sodium hypophosphite under microwave irradiation
Meshram,Ganesh,Sekhar, K. Chandra,Yadav
, p. 993 - 994 (2007/10/03)
The selective reduction of nitro group into amine using sodium hypophosphite under microwave irradiation is described. The rapid reaction, solvent free conditions and selectivity over common functional groups like CN, OH, COOH, CONH2 and halogens are the distinct features of the procedure.
