380241-58-7

Basic information

• Product Name: 4-AMINO-2-CHLORO-5-IODOBENZONITRILE
• Synonyms: 4-AMINO-2-CHLORO-5-IODOBENZONITRILE
• CAS NO: 380241-58-7
• Molecular Formula: C₇H₄ClIN₂
• Molecular Weight: 278.48
• Mol File: 380241-58-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 370.5±42.0 °C(Predicted)
• Appearance: /
• Density: 2.07±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.40±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-2-CHLORO-5-IODOBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-CHLORO-5-IODOBENZONITRILE(380241-58-7)
• EPA Substance Registry System: 4-AMINO-2-CHLORO-5-IODOBENZONITRILE(380241-58-7)

Safety Data

• Hazardous Substances Data: 380241-58-7(Hazardous Substances Data)

Usage

General Description

4-AMINO-2-CHLORO-5-IODOBENZONITRILE is a chemical compound that is classified as a benzene derivative. It is a white to off-white powder with a molecular formula C7H4ClIN2. This chemical is used in organic synthesis and pharmaceutical research as an intermediate in the production of various drugs and agrochemicals. It has also been investigated for its potential use as a corrosion inhibitor in the automotive and aerospace industries. 4-AMINO-2-CHLORO-5-IODOBENZONITRILE is a highly reactive compound and should be handled with caution in a controlled laboratory setting.

Upstream product

• 20925-27-3 4-amino-2-chlorobenzonitrile 

Downstream Products

• 380241-67-8 N-(5-chloro-4-cyano-2-iodophenyl)methanesulfonamide 
• 869214-90-4 (5-chloro-4-cyano-2-iodo-phenyl)-carbamic acid tert-butyl ester 
• 643744-98-3 [3-chloro-4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-carbamic acid tert-butyl ester 
• 643744-97-2 [5-chloro-2-iodo-4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-carbamic acid tert-butyl ester 
• 643745-03-3 2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide 
• 380241-79-2 6-chloro-2-[2-[(2-methoxyethoxy)methoxy]biphenyl-3-yl]-1H-indole-5-carbonitrile 
• 277313-31-2 6-Chloro-2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-1H-indole-5-carboxamidine 
• 277313-30-1 6-chloro-N-hydroxy-2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-1H-indole-5-carboxamidine 
• 1425933-52-3 4-amino-2-chloro-5-ethynylbenzonitrile 
• 1423120-66-4 6-chloro-1H-indole-5-carbonitrile 
• 1425933-51-2 4-amino-2-chloro-5-((trimethylsilyl)ethynyl)benzonitrile 

Relevant articles and documents

NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS

The present invention discloses compounds according to Formula (I), wherein R1, R3, R4, R5, L1, and Cy are as defined herein. The present invention also provides compounds, methods for the production of said compounds of the invention, pharmaceutical compositions comprising the same and their use in allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 and/or interferons. The present invention also methods for the prevention and/or treatment of the aforementioned diseases by administering a compound of the invention.

Environmentally friendly and efficient: Iron-mediated reduction of 3-methyl-5-aryl-1,2,4-oxadiazoles to benzamidines

A new synthetic method is described for the mild and selective reduction of 3-methyl-5-aryl-1,2,4-oxadiazoles to amidines employing iron powder in aqueous medium. Its application is demonstrated in the synthesis of 1, a potent and selective urokinase-type plasminogen activator (uPA) inhibitor.