346600-25-7

Basic information

• Product Name: 3,3-DibroMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
• Synonyms: 3,3-DibroMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
• CAS NO: 346600-25-7
• Molecular Formula: C₇H₃Br₂ClN₂O
• Molecular Weight: 326.37252
• Mol File: 346600-25-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,3-DibroMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-DibroMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(346600-25-7)
• EPA Substance Registry System: 3,3-DibroMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(346600-25-7)

Safety Data

• Hazardous Substances Data: 346600-25-7(Hazardous Substances Data)

Upstream product

• 55052-28-3 4-chloro-7-azaindole 

Downstream Products

• 346599-62-0 4-chloro-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one 
• 1528549-21-4 C₁₃H₁₀FN₃O₂ 

Relevant articles and documents

BIARYL KINASE INHIBITORS

The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.

PHARMACEUTICAL COMPOUNDS

The invention provides compounds of the formula (I): or salts, solvates, tautomers or N-oxides thereof, wherein J1-J2 is CH=CH, N=CH, CH=N, HN-C(O) or CH2CO; T is N or CH and GP is as defined in the claims. The compounds have activity as inhibitors of PKA and PKB kinases and are useful in the treatment of cancers.

4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors

This invention relates to 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors. Particular 4-substituted 7-aza-indolin-2-ones disclosed herein are of Formula 1 and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, X, Y, and Z are defined herein. The invention fuirther relates to pharmaceutical compositions and dosage forms comprising compounds of Formula 1 and to methods of their use for the treatment and/or prevention of diseases such as, but not limited to, cancer.