346599-62-0

Basic information

• Product Name: 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
• Synonyms: 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;4-Chloro-1H-pyrrolo[2,3-b...;4-Chloro-7-aza-2-oxindole;3-b]pyridin-2(3H)-one;4-chloro-1H-pyrrolo[2;4-chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one;2H-Pyrrolo[2,3-b]pyridin-2-one, 4-chloro-1,3-dihydro-;4-Chloro-1,3-dihydropyrrolo[2,3-b]pyridin-2-one
• CAS NO: 346599-62-0
• Molecular Formula: C₇H₅ClN₂O
• Molecular Weight: 168.58
• Product Categories: CHIRAL CHEMICALS
• Mol File: 346599-62-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 372.983 °C at 760 mmHg
• Flash Point: 179.374 °C
• Appearance: /
• Density: 1.45 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.61
• PKA: 11.65±0.20(Predicted)
• CAS DataBase Reference: 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(346599-62-0)
• EPA Substance Registry System: 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(346599-62-0)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 346599-62-0(Hazardous Substances Data)

Usage

General Description

4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one is a chemical compound with the molecular formula C7H5ClN2O. It is a heterocyclic compound containing a pyrrole ring fused to a pyridine ring with a chlorine atom attached to the 4-position. 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one has been found to have potential pharmacological activities, including anti-fungal and anti-tumor properties. It has also been investigated for its potential use in the development of new drugs. Additionally, it has been used in research as a building block for the synthesis of novel compounds with potential biological activities.

InChI:InChI=1/C7H5ClN2O/c8-5-1-2-9-7-4(5)3-6(11)10-7/h1-2H,3H2,(H,9,10,11)

Upstream product

• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 346600-25-7 3,3-dibromo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 
• 55052-28-3 4-chloro-7-azaindole 
• 271-63-6 7-Azaindole 
• 74420-18-1 7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate 

Downstream Products

• 956460-59-6 [1-(2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester 
• 956462-75-2 [1-(2,3-dioxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester 
• 346600-27-9 5-(4-chloro-2-oxo-1,2-dihydro-pyrrolo [2,3-b]pyridin-3-ylidenemethyl)-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide 
• 1528549-21-4 C₁₃H₁₀FN₃O₂ 

Relevant articles and documents

BIARYL KINASE INHIBITORS

The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.

SUBSTITUTED PIPERIDINES CONTAINING A HETEROARYLAMIDE OR HETEROARYLPHENYL MOIETY

The invention provides compounds of the formula (I) having PKA and PKB kinase inhibiting compounds of the formula (I): GP 1 J T 2 J N 4 R N H (I) or salts, solvates, tautomers or N-oxides thereof, wherein (1) GP is a group GP1: HET 2a a Q G (HNCO)f 7 (R )x N * (GP1) (2) GP is a group GP2: 10 (R )r O 2a a QG (CH2)w N V H N * (GP2) wherein HET is a monocyclic or bicyclic heterocyclic group containing up to 4 heteroatom ring members; the ring V is a monocyclic or bicyclic heteroaryl group of 5 to 10 ring members; and J1, J2, R4, R7, R10, Q2a, Ga, x, w and f are as defined in the claims

PHARMACEUTICAL COMPOUNDS

The invention provides compounds of the formula (I): or salts, solvates, tautomers or N-oxides thereof, wherein J1-J2 is CH=CH, N=CH, CH=N, HN-C(O) or CH2CO; T is N or CH and GP is as defined in the claims. The compounds have activity as inhibitors of PKA and PKB kinases and are useful in the treatment of cancers.