55052-24-9

Basic information

• Product Name: 7-OXIDE-7-AZAINDOLE
• Synonyms: 1H-Pyrrolo[2,3-β]pyridine 7-Oxide;1H-Pyrrolo[2,3-β]pyridine-N-oxide;1H-Pyrrolo[2,3-b]pyridine, 7-oxide;1H-Pyrrolo[2,3-b]pyridine-N-oxide;7-Azaindole N-oxide hemihydrate;7-Azaindole-7-oxide;7-Oxide-7-azaindole ,98%;7H-1$l^{5},7-pyrrolo[2,3-b][1$l^{5}]pyridin-1-one
• CAS NO: 55052-24-9
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.137
• Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Heterocycle-Pyridine series
• Mol File: 55052-24-9.mol
• Article Data: 84

Chemical Properties

• Melting Point: 126-1280C
• Boiling Point: 352.677°C at 760 mmHg
• Flash Point: 167.093°C
• Appearance: /
• Density: 1.331g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: Refrigerator
• Solubility: Chloroform, DMSO, Methanol
• PKA: 12.68±0.40(Predicted)
• CAS DataBase Reference: 7-OXIDE-7-AZAINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-OXIDE-7-AZAINDOLE(55052-24-9)
• EPA Substance Registry System: 7-OXIDE-7-AZAINDOLE(55052-24-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26
• RIDADR: UN 2811 6.1/PG 3
• Hazardous Substances Data: 55052-24-9(Hazardous Substances Data)

Usage

Description

7-OXIDE-7-AZAINDOLE, also known as 1H-Pyrrolo[2,3-b]pyridine 7-Oxide, is an organic compound with the CAS number 55052-24-9. It is a beige solid and is primarily used in the field of organic synthesis due to its unique chemical properties.

Uses

Used in Organic Synthesis:
7-OXIDE-7-AZAINDOLE is used as a synthetic building block for the development of various organic compounds. Its unique structure allows it to be a versatile component in the synthesis of complex molecules, which can be utilized in different industries such as pharmaceuticals, agrochemicals, and materials science.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 7-OXIDE-7-AZAINDOLE is used as a key intermediate in the synthesis of various drug candidates. Its incorporation into the molecular structure can potentially enhance the pharmacological properties of the final product, leading to improved therapeutic outcomes.
Used in Agrochemical Industry:
7-OXIDE-7-AZAINDOLE is also used in the agrochemical industry for the development of novel pesticides and other agrochemical products. Its unique chemical properties can contribute to the creation of more effective and environmentally friendly solutions for crop protection and management.
Used in Materials Science:
In the field of materials science, 7-OXIDE-7-AZAINDOLE can be used as a component in the development of advanced materials with specific properties. Its incorporation into the molecular structure can lead to the creation of materials with enhanced performance characteristics, such as improved stability, reactivity, or selectivity.

InChI:InChI=1/C7H6N2O/c10-9-5-1-2-6-3-4-8-7(6)9/h1-5,8H

Upstream product

• 271-63-6 7-Azaindole 
• 74420-18-1 7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate 
• 1374585-47-3 7-hydroxy-1H-pyrrolo[2,3-b]pyridinium 3-chloroperoxybenzoate 
• 272-49-1 1H-pyrrolo[3,2-b]pyridine 

Downstream Products

• 143468-11-5 1-Benzoyl-6-chloro-1H-pyrrolo<2,3-b>pyridine 
• 143468-08-0 1-Benzoyl-6-cyano-1H-pyrrolo<2,3-b>pyridine 
• 143468-07-9 6-Chloro-1-methoxycarbonyl-1H-pyrrolo<2,3-b>pyridine 
• 143468-09-1 1-Methoxycarbonyl-6-thiocyanato-1H-pyrrolo<2,3-b>pyridine 
• 143468-12-6 1-Benzoyl-6-bromo-1H-pyrrolo<2,3-b>pyridine 
• 74420-07-8 3-nitro-1H-pyrrolo<2,3-b>pyridine 7-oxide 
• 74420-06-7 4-nitro-1H-pyrrolo<2,3-b>pyridine 7-oxide 
• 55052-28-3 4-chloro-7-azaindole 
• 348640-06-2 4-bromo-7-azaindole 
• 769961-36-6 4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzene-1,2-diamine 
• 952490-59-4 4-(3,4-dinitro-phenoxy)-1H-pyrrolo[2,3-b]pyridine 
• 769961-42-4 4-(4-benzyloxy-phenoxy)-1H-pyrrolo[2,3-b]pyridine 
• 769961-59-3 4-(1H-indol-4-yloxy)phenol 
• 769961-52-6 4-(1H-indol-4-yloxy)-2-aminophenol 

Relevant articles and documents

Synthesis and structure?activity?relationship of 3,4?Diaryl?1H?pyrrolo[2,3?b]pyridines as irreversible Inhibitors of mutant EGFR?L858R/T790M

The epidermal growth factor receptor (EGFR) is a well?validated drug target for the treatment of non?small cell lung cancer. Here we present an optimization approach and preliminary structure?activity relationship for 1H?pyrrolo[2,3?b]pyridines as covalent irreversible mutant EGFR inhibitors. We synthesized a focused library to investigate the effect of different aromatic substituents in the 4?position of this scaffold, interacting with the gatekeeper. We determined the activity of the synthesized compounds mutant EGFR enzyme assays and determined the selectivity over the wild type.

Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia

Serine/threonine-protein kinases 3 and 4 (STK3 and STK4, respectively) are key components of the Hippo signaling pathway, which regulates cell proliferation and death and provides a potential therapeutic target for acute myeloid leukemia (AML). Herein, we

AZAINDOLE CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS

Provided herein are compounds of Formula (I) and Formula (II): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of tuberculosis.

MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES

The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.